會計學1FabricationofMiniaturizedAcousticalLensesforHigh高的微型聲學透鏡制造MaterialsCharacterization-FacilitiesEquipment&TechniquesUHVSurfaceAnalysisSystem(XPS,UPS,Auger,…)surfacechemistryandelectronicbandstructure,in-situsurfacemodificationUltrafast(femto-sec)TransientAbsorptionSpectroscopyFieldEmissionGunTransmissionElectronMicroscope(FEGTEM)high-resolutionimaging,diffraction,andchemistryScanningElectronMicroscope(SEM)morphologyandelementalanalysisX-RayDiffraction(XRD)bulkphaseidentification,crystallography,phasetransformationsThermalAnalysis–DSC&TGAheatcapacity,meltingpoint,freezingpoint,etc.Photoluminescence/RamanSpectrometer(PL/Raman)emissionefficiency,band-gap,Ramanshifts(sensitivetobonding)FourierTransformIRSpectrometer(FTIR)localvibrationalmodes(sensitivetoimpuritiesandbonging)ParticleSizeDistribution(PSD)TeamJacekJasinski–ThemeLeaderRodicaMcCoy–LabManagerTimothyGutu–Post-doctoralScholarMeysamAtkhar–Grad.Student(Physics)RodicaJacekTimMeysam第1頁/共14頁THENANO-LABORATORY

ElectronMicroscopewithjoystickcontrolNanoneedlesshownontopmonitorsNanofiberair-bridgesspanmicropillarsonbottommonitorsTheHusonNanotechnologyCoreFacilitypursuescollaborativeresearchinelectrooptics&nanotechnology.Membersuseuniquetoolsforreal-timefab&characterizationofnanostructures.第2頁/共14頁TheJohnJ.HusonandMariaMeekHusonNanotechnologyCoreFacility(HNCF)Contacts:R.W.CohnorJ.P.Williams(SRB106)HNCFhousesacompletesuiteofnanotoolsforimaging,manipulation,probing,fabricationandmaterialsanalysisofnanostructureddevicesandmaterials.HNCFisashareduserfacilityopentostudentsandfacultyuponcompletionoftraining.Majorequipmentincludes:ScanningElectronMicroscopes(1nmresolution)+accessories:

EnergyDispersiveX-RaySpectroscopy—AtomiccompositionanalysesScanningTransmissionMicroscopy—ImagingthroughthinsamplesVariablePressure–ForstudyingwetsamplesandchangeswithhumidityNanomanipulators–Electrical/mechanicalprobing&fabofnanostructuredmatterAtomicForceMicroscopes(AFM)+options:

Atomicscaletopography,viscoelasticmappingofsoftmatter&polymers,conductivemapping,measurementsofadhesion,friction,wetting,anti-bodybindingandproteinunfoldingforces BIO-AFM:CombinedAFMandfluorescentimagingwithabiologicalmicroscope

AutomatedChemicalPress(5nmresolution)withcontrollableUV,thermalandpressureEllipsometer–Measurerefractiveindex&thicknessofsingle&multilayerfilms&coatingsNon-contactopticalprofilingmicroscope(1nmverticalresolution)ExtensionalRheometer–Measuresextensionalviscosityofpolymericliquids第3頁/共14頁LoDIExpertiseIntelligent-agentbased,real-timedecisionsupportsystemsforAS/RSandHealthcareLogisticsERprocessimprovementFacilityLocationforPediatricsPhysiciansSchedulingDeterministicandstochasticoptimizationfor:EmergencycallcenterplanningSkillsManagement/WorkforcePlanningSupplychainmanagement,logistics,layout,location,orderpicking,warehouselayoutDesignandAnalysisofAutomatedStorage&RetrievalSystemsApplicationofRFIDtoimproveintra-andinter-plantlogisticsIntegrationofdesignandplanninginadvancedlogisticalsystemsSimulationmodelsforwarehouseperformanceanalysisOptimalgoodsdistributionDesignofnextgenerationfactorylayouts第4頁/共14頁HospitalPatientAllocation第5頁/共14頁第6頁/共14頁MicroNanoTechnologyCleanroom(MNTC)

$30M,10,000sqftstate-of-the-artfacilityDr.KevinWalsh,FoundingDirectorClass100/1000,OpenedSummer2006Rankedtop10inUSAbySmallTimesMagazineMicro/nano/bioresearchthrustOver100usersfrom8Depts$5Mofresearchayear(1/3ofSpeedtotal)Produced5Startupsandover25PatentsUsedby5classestotrainU/GstudentsOutreach–500kidsayrtourcleanroomAdvancedModelingandPackagingLabsHomeforInterdisciplinaryResearchEngineeringPhysicsChemistryBiologyMedicine

SUMMARY第7頁/共14頁SamplePrototypeDevices(Wecanmakeanythingyoucanimagine)Micro-NeedlesMicroCagesforCellsLab-on-a-ChipSystemsImplantablePressureSensorsRFTemperatureSensorforAircraftTiresMicro-hotplateExplosivePreconcentratorWirelessGlaucomaSensorFlowSensorGasSensorThermalActuatorMEMSAccelerometer第8頁/共14頁WallaceH.CoulterTranslationalPartnershipAwardAwardedtotheUniversityofLouisvilleDepartmentofBioengineeringin2011$5Milliongrantprogram(over5years)Programgoals:AddresssignificantunmetclinicalneedorcostreductionProvides“gapfunding”fortranslationalresearchAwardsaretypically~$100,000PromotemedicalinnovationthroughEngineer-PhysicianPartnershipProvidearoadmapforcommercializationofUniversitytechnologyMilestonedrivenProprietarytechnology/Technologydevelopmentstage/businessplanFollow-onfundingpotentialExpectedoutcomes:Inventions,patents,improveddiagnosisandtreatmentofdisease,commercialproducts,licenses,partnershipsandstart-upcompanies第9頁/共14頁TimelinePre-proposalsdue:November16,2012Fullproposalinvitations:December14,2012Fullproposalsdue:February1,2013AnnouncementofProjectsInvitedforPresentation:TBD(April2013)PresentationstoOversightCommittee:TBD

(May/June2013)FundingStartDate:July1,2013第10頁/共14頁VentureCapitalandEntrepreneurMembersGeorgeEmont(Triathlon/KYSeedCapitalFund)StevenGailar(MetaCyte/KYSeedCapitalFund)CarterMcNabb(RiverCityCapital)PaulSpence,MD(SCR,Inc)SchoolofMedicineMembers/ClinicalHenryKaplan,MD(Ophthalmology)CraigMcClain,MD,PhD(GI)DonaldMiller,MD,PhD(Oncology)MarkSlaughter,MD(Cardiovascular)OTTHollySymondsClark,PhDMeleaEast,JDCoulterPrincipalInvestigatorRobertKeynton,PhDCoulterFoundationmemberMikeGara

TranslationalResearchPartnershipOversightCommittee第11頁/共14頁BioengineeringPrincipalInvestigatorRobertKeynton,PhDChair,ProfessorandLutzEndowedChairofBiomechanicalDevicesDepartmentofBioengineering,SpeedSchoolofEngineeringSchoolofMedicineMarkSlaughter,MDProfessorandChief DivisionofThoracicandCardiovascularSurgery

UniversityofLouisvilleSchoolofMedicine

CoulterTeamUofLOfficeofTechnol