1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECromolyn sodiumCat. No.: HY-B0320ACAS No.: 15826-37-6Synonyms: Disodium Cromoglycate; FPL-670分式: CHNaO分量: 512.33作靶點: Calcium Channel; GSK-3作通路: Membrane Transporter/Ion Channel; Neuronal Signaling;PI3K/Akt/mTOR; Stem Cell/Wnt儲存式

2、: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 H2O : 32 mg/mL (62.46 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.9519 mL 9.7593 mL 19.5187 mL5 mM 0.3904 mL 1.9519 mL 3.9037 mL10 mM 0.1952 mL 0.9759 mL 1.9519 mL請根據(jù)產(chǎn)品在不同

3、溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 Cromolyn sodium is dissolved in PBS3.BIOLOGICAL ACTIVITY物活性 Cromolyn sodium抗過敏化合物。Cromolyn sodium 種 GSK-3 抑制劑，IC50 為 2.0 M。1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEIC50 & Target GSK-32 M (IC50)體外研究 Cromolyn (sodium) is a chromone complex that acts by

4、inhibiting the release of chemical mediators fromsensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma,but does not affect an established asthmatic attack.體內(nèi)研究 Pretreatment of IIR mice with Cromolyn (sodium) prior to ischemia exhibited no change

5、s of ET-1 levels, injuryscore and inflammation (P0.05, PreCr vs. M groups). In conclusion, administration of Cromolyn (sodium)after reperfusion, but not prior to ischemia, attenuates IIRI by downregulating ET-1 and suppressingsustained MC activation 1. Cromolyn (sodium) has a role in the prevention

6、of Chronic lung disease(CLD).Cromolyn (sodium) cannot be recommended for the prevention of CLD in preterm infants 2.戶使本產(chǎn)品發(fā)表的科研獻 Pharmacol Res. 2017 Nov;125(Pt B):150-160.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Gan, X., et al., Treatment of mice with cromolyn sodium afte

7、r reperfusion, but not prior to ischemia, attenuates small intestinal ischemia-reperfusion injury. Mol Med Rep, 2013. 8(3): p. 928-34.2. Ng, G. and A. Ohlsson, Cromolyn sodium for the prevention of chronic lung disease in preterm infants. Cochrane Database Syst Rev,2012. 6: p. CD003059.3. Huang L, et al. Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via inhibiting NF-Bsignaling. Pharmacol Res. 2017 Aug 31. pii: S1043-6618(17)30796-X.McePdfHeightCaution: Product has not been fully validated for medical applications.For r