1、Age-related diseases and cancer COENZYME ICOENZYME IP-1P-2P-3Eric Verdin. (2015). Special Section 350（6265）: 1208-1213.P-4NAD biosynthetic pathways and metabolism in different cellular compartments.P-5E F. Fang,. (2017). NAD+: a key metabolic regulator with great therapeutic potential: 1120-1143.P-6

2、NAD availability can influence the activity of three groups of master regulator enzymesthe sirtuins, the PARPs and cyclic ADP-ribose synthases. Each group of enzymes regulate many biological processes and can thus couple changes in NAD levels with a wide range of physiological responses.P-71980s1980

3、s1930s1930sP-8Age-related diseases and cancer could be the consequence of a decline in NAD+ concentrationsAmanda Garrido (2017). Trend in cancer 181: 181-199.Metabolic syndrome including cardiovascular disorders, type 2 diabetes and obesity, Neurodegenerative diseases such as Alzheimer and Parkinson

4、diseases, arthritis, and osteoporosis, and cancer are some of the diseases that commonly affect human health during aging.P-9GSultani. (2017). Trends in Molecular Medicine23（10）: 900-918P-10GSultani. (2017). Trends in Molecular Medicine23（10）: 900-918P-11GSultani. (2017). Trends in Molecular Medicine23（10）: 900-918P-12P-13GSultani. (2017). Trends in Molecular Medicine23（10）: 900-918P-14GSultani. (2017). Trends in Molecular Medicine23（10）: 900-918P-15GSultani. (2017). Trends in Molecular Medicine23（10）: 900-918P-15G