Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEMebeverinehydrochlorideCat.No.:HY-A0078CASNo.:2753-45-9分?式:C??H??ClNO?分?量:466.01作?靶點(diǎn):SodiumChannel作?通路:MembraneTransporter/IonChannel儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:≥155mg/mL(332.61mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.1459mL10.7294mL21.4588mL5mM0.4292mL2.1459mL4.2918mL10mM0.2146mL1.0729mL2.1459mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?，-20°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性Mebeverinehydrochlorideβ-苯?胺的衍?物，?種增肌劑，可有效阻?腸道蠕動(dòng)。Mebeverinehydrochloride直接阻斷電壓控制的鈉通道(voltage-operatedsodiumchannels)，抑制細(xì)胞內(nèi)鈣的積累。體外研究Mebeverinehydrochlorideinhibitstheα1actionbylimitingtheamountofavailablecalciummobilizedon1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEreceptorstimulationofthesmoothmusclecellsofguinea-pigtaeniacaeci.Mebeverine(6×10-6M)hydrochlorideshowsatropine-likepropertiesbyshiftingtotherighttheconcentration-responsecurveobtainedwithcarbachol.Theα1-receptor-inducedhyperpolarizationcausedbyadrenaline(3×10-6M)inthepresenceofmebeverinedeclinesafterreachinganinitialmaximum.Mebeverine(6×10-5M)hydrochloridecausesasmallhyperpolarizationofthemusclecells(2.1+0.5mV)andsuppressionofspikeactivity[2].REFERENCES[1].DenHertogA,etal.Modificationofalpha1-receptor-operatedchannelsbymebeverineinsmoothmusclecellsofguinea-pigtaeniacaeci.EurJPharmacol.1987Jun26;138(3):367-74.[2].AnnaháziA,etal.Roleofantispasmodicsinthetreatmentofirritablebowelsyndrome.WorldJGastroenterol.2014;20(20):6031-6043.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3