1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEZ433927330Cat. No.: HY-126074CAS No.: 1005883-72-6分式: CHNO分量: 364.4作靶點: Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數據體外實驗 DMSO : 280 mg/mL (768.39 mM)* means soluble, but saturation

2、 unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.7442 mL 13.7212 mL 27.4424 mL5 mM 0.5488 mL 2.7442 mL 5.4885 mL10 mM 0.2744 mL 1.3721 mL 2.7442 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗 請根據您的實驗動物和給藥式選擇適當的溶解案，配制前請先配制澄清的儲備液，再依次添加助溶劑(為保證實驗結果的可靠性，體內實驗的作液，建議您現現配，當天使；澄清的儲備液可以根據儲存條件，

3、適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.33 mg/mL (6.39 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.33 mg/mL (6.39 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Z43392733

4、0種有效、選擇性的通道蛋 Aquaporin-7 (AQP7) 的抑制劑，對 AQP3 和 AQP9的抑制作較弱，對 mAQP7，mAQP3 和 mAQP9 的 IC50 值分別為-0.2 M，0.7 M 和 1.1 M 1。IC50 & Target IC50: 0.2 M (mAQP7), 0.7 M (mAQP3), 1.1 M (mAQP9) 1體外研究 Z433927330 inhibits glycerol permeability, with an IC50 of 0.6 M 1.REFERENCES1. Z433927330, et al. Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. J Biol Chem. 2019May 3;294(18):7377-7387.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>