1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEHydroxyzine dihydrochlorideCat. No.: HY-B0548ACAS No.: 2192-20-3分式: CHClNO分量: 447.83作靶點(diǎn): Histamine Receptor作通路: GPCR/G Protein; Immunology/Inflammation; NeuronalSignaling儲(chǔ)存式: 4C, protect from light* In solvent : -80C, 6 months;

2、-20C, 1 month (protect fromlight)溶解性數(shù)據(jù)體外實(shí)驗(yàn) H2O : 150 mg/mL (334.95 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.2330 mL 11.1650 mL 22.3299 mL5 mM 0.4466 mL 2.2330 mL 4.4660 mL10 mM 0.2233 mL 1.1165 mL 2.2330 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存

3、式和期限。BIOLOGICAL ACTIVITY物活性 Hydroxyzine 雙鹽酸鹽是組胺 H1 受體拮抗劑。REFERENCES1. Minogiannis, P., et al., Hydroxyzine inhibits neurogenic bladder mast cell activation. Int J Immunopharmacol, 1998. 20(10): p. 553-63.2. Dimitriadou, V., X. Pang, and T.C. Theoharides, Hydroxyzine inhibits experimental allergic en

4、cephalomyelitis (EAE) and associated1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEbrain mast cell activation. Int J Immunopharmacol, 2000. 22(9): p. 673-84.3. Kan, W.M., et al., Effect of hydroxyzine on the transport of etoposide in rat small intestine. Anticancer Drugs, 2001. 12(3): p. 267-73.4. Morichi, R. and G. Pepeu, A study of the influence of hydroxyzine and diazepam on morphine antinociceptoion in the rat. Pain, 1979.7(2): p. 173-80.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589559