1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAlprenolol hydrochlorideCat. No.: HY-B1517ACAS No.: 13707-88-5Synonyms: (RS)-Alprenolol hydrochloride; dl-Alprenolol hydrochloride分式: CHClNO分量: 285.81作靶點: 5-HT Receptor作通路: GPCR/G Protein; Neuronal Signaling儲存式: Powder -20C 3 ye

2、ars4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數據體外實驗 DMSO : 100 mg/mL (349.88 mM; Need ultrasonic)H2O : 50 mg/mL (174.94 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.4988 mL 17.4941 mL 34.9883 mL5 mM 0.6998 mL 3.4988 mL 6.9977 mL10 mM 0.3499 mL 1.7494 mL 3.4988 mL請根

3、據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗請根據您的實驗動物和給藥式選擇適當的溶解案，配制前請先配制澄清的儲備液，再依次添加助溶劑(為保證實驗結果的可靠性，體內實驗的作液，建議您現現配，當天使；澄清的儲備液可以根據儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 3 mg/mL (10.50 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (2

4、0% SBE-CD in saline)Solubility: 3 mg/mL (10.50 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 3 mg/mL (10.50 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Alprenolol鹽酸鹽個選擇性的beta阻斷劑，也是5-HT1A受體的拮抗劑。REFERENCES1. Schreiber R et al. Involvem

5、ent of 5-HT1A receptors in the anxiolytic action of S 14671 in the pigeon conflict test. Pharmacol BiochemBehav. 1995 Jun-Jul;51(2-3):211-5.2. Millan MJ et al. Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1Aautoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. J Pharmacol Exp Ther, 1994 Jan, 2McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792