Alzheimer’sDisease阿爾茨海默癥

Alzheimer’sDisease阿爾茨海默癥1RonaldWilsonReagan羅納德·威爾遜·里根第40任（第49-50屆）美國總統president“IknowI'monmywaytothetwilight.Iknowthere'salwaysabrightdawnaheadoftheUnitedstates.Thankyou,myfriends.MayGodblessyouforever.”2RonaldWilsonReagan第40任（第49-5briefintroduction01Pathogeny＆Treatment03Clinicalmanifestation02Other04Catalogbriefintroduction0103Clinical3

briefintroduction

14

briefintroduction

14What?Alzheimer'sdisease(AD)isaprogressiveneurodegenerativedisorder.臨床癥狀Clinicalsymptom記憶障礙dysmnesia失語aphasia失認agnosia執行功能障礙executivedysfunction癡呆dementiaThediseaseusuallybeginsafterage60,andriskgoesupwithage.5What?Alzheimer'sdisease(AD)TwotypesAlzheimer'sdisease(AD)

<65yearsoldseniledementia(SDAT)≥65yearsold6TwotypesAlzheimer'sdisease(ANameIn1906,ADisnamedbyDr.AloisAlzheimer,aGermandoctor.Dr.Alzheimernoticedchangesinthebraintissueofawomanwhohaddiedofanunusualmentalillness.Hefoundabnormalclumps.ScientistsalsohavefoundotherbrainchangesinpeoplewithAD.Nervecellsdieinareasofthebrainthatarevitaltomemoryandothermentalabilities.7NameIn1906,ADisnamedbyDr.

Clinicalmanifestation

28

Clinicalmanifestation

28Clinicalmanifestation

Ⅰ期Ⅱ期Ⅲ期death1-3

years2-10

years8-12yearsMilddementiaModeratedementiaSeveredementiaMorewomenthanmen7:5~4:6Diseaseforupto10-20years9Clinicalmanifestation

Ⅰ期Ⅱ期Ⅲ期d

DegradationofmemoryandcognitionWilliamUtermohlen的自畫像

Degradationofmemoryandc10Degradationofmemoryandcognition

WilliamUtermohlenisanAmericanartist,in1995hewasdiagnosedwithAlzheimer'sdisease.Sincethen,hehasdecidedtotakeadvantageofthelimitedtimeavailabletoretainmemoryandbetterunderstandhimselfthroughselfportraits.Williaminsistedthe5NewYearpaintingsselfportrait,untilcompletelyforgottenhowtodraw.Fromtheuseofskilleddrawing,darkportrayalofvividfeatures,tothesamecolor,shapedeformation,selfportraitbecamemoreandmoreabstract(picturedabove).Degradationofmemoryandcogn11Degradationofmemoryandcognition

"theeffectsofAlzheimer'sdiseaseontherightparietallobeofthebrainareparticularlysevere,whichdirectlyaffectstheabilityofthebraintovisualizeanddeveloptheabilitytodrawpicturesofthebrain."saidDr.BruceMiller,aneurologist.Hisworkbecamemoreabstract,maybetheparietalfunctiondamaged,causingblindness.Whatkindofchangeshaveoccurredinthebrainsofpatientswithdementia,whichisnotyetfullyunderstoodbytheworld'sacademia.Degradationofmemoryandcogn12

Pathogeny＆Treatment

3

Pathogeny＆Treatment

313PathogenesishypothesisofAD14PathogenesishypothesisofAD1PathogenyAbnormalamyloidbetacelldepositioninneuronsAbnormalphosphorylationoftauproteinvs15PathogenyAbnormalamyloidbetaBetaamyloid(bluecurve)andTauprotein(orangecurve)Researchpaperspublishedinrecent30yearsBetaamyloid(bluecurve)and16Treatmentincreasetheconcentrationofacetylcholine(Ach)inthebrainpromotingsurvivalofcholinergicneuronsinthebrainorimprovingtheirnerveconductionfunctionreducingtheproductionorpromotingdegradationofbetaamyloidTreatmentincreasetheconcentr17Other4Other418StillAliceFilmThefilmtellsthestoryofAliceHowlandinseriouslyADbutstillstrongandbrave.Thefilmwontheeighty-seventhOscaraward19StillAliceFilmThefilmtellsTheNotebookMemoriesofTomorrow20MemoriesofTomorrow20Thank

you21Thank

you21Alzheimer’sDisease阿爾茨海默癥

Alzheimer’sDisease阿爾茨海默癥22RonaldWilsonReagan羅納德·威爾遜·里根第40任（第49-50屆）美國總統president“IknowI'monmywaytothetwilight.Iknowthere'salwaysabrightdawnaheadoftheUnitedstates.Thankyou,myfriends.MayGodblessyouforever.”23RonaldWilsonReagan第40任（第49-5briefintroduction01Pathogeny＆Treatment03Clinicalmanifestation02Other04Catalogbriefintroduction0103Clinical24

briefintroduction

125

briefintroduction

14What?Alzheimer'sdisease(AD)isaprogressiveneurodegenerativedisorder.臨床癥狀Clinicalsymptom記憶障礙dysmnesia失語aphasia失認agnosia執行功能障礙executivedysfunction癡呆dementiaThediseaseusuallybeginsafterage60,andriskgoesupwithage.26What?Alzheimer'sdisease(AD)TwotypesAlzheimer'sdisease(AD)

<65yearsoldseniledementia(SDAT)≥65yearsold27TwotypesAlzheimer'sdisease(ANameIn1906,ADisnamedbyDr.AloisAlzheimer,aGermandoctor.Dr.Alzheimernoticedchangesinthebraintissueofawomanwhohaddiedofanunusualmentalillness.Hefoundabnormalclumps.ScientistsalsohavefoundotherbrainchangesinpeoplewithAD.Nervecellsdieinareasofthebrainthatarevitaltomemoryandothermentalabilities.28NameIn1906,ADisnamedbyDr.

Clinicalmanifestation

229

Clinicalmanifestation

28Clinicalmanifestation

Ⅰ期Ⅱ期Ⅲ期death1-3

years2-10

years8-12yearsMilddementiaModeratedementiaSeveredementiaMorewomenthanmen7:5~4:6Diseaseforupto10-20years30Clinicalmanifestation

Ⅰ期Ⅱ期Ⅲ期d

DegradationofmemoryandcognitionWilliamUtermohlen的自畫像

Degradationofmemoryandc31Degradationofmemoryandcognition

WilliamUtermohlenisanAmericanartist,in1995hewasdiagnosedwithAlzheimer'sdisease.Sincethen,hehasdecidedtotakeadvantageofthelimitedtimeavailabletoretainmemoryandbetterunderstandhimselfthroughselfportraits.Williaminsistedthe5NewYearpaintingsselfportrait,untilcompletelyforgottenhowtodraw.Fromtheuseofskilleddrawing,darkportrayalofvividfeatures,tothesamecolor,shapedeformation,selfportraitbecamemoreandmoreabstract(picturedabove).Degradationofmemoryandcogn32Degradationofmemoryandcognition

"theeffectsofAlzheimer'sdiseaseontherightparietallobeofthebrainareparticularlysevere,whichdirectlyaffectstheabilityofthebraintovisualizeanddeveloptheabilitytodrawpicturesofthebrain."saidDr.BruceMiller,aneurologist.Hisworkbecamemoreabstract,maybetheparietalfunctiondamaged,causingblindness.Whatkindofchangeshaveoccurredinthebrainsofpatientswithdementia,whichisnotyetfullyunderstoodbytheworld'sacademia.Degradationofmemoryandcogn33

Pathogeny＆Treatment

3

Pathogeny＆Treatment

334PathogenesishypothesisofAD35PathogenesishypothesisofAD1PathogenyAbnormalamyloidbetacelldepositioninneuronsAbnormalphosphorylationof