1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETat-NR2B9c TFACat. No.: HY-P0117ACAS No.: 1834571-04-8Synonyms: NA-1 (TFA)分式: CHFO分量: 114.02Sequence: Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Leu-Ser-Ser-Ile-Glu-Ser-Asp-ValSequence Shortening:YGRKKRRQRRRKLSSIESDV作靶點: iG

2、luR; NO Synthase作通路: Membrane Transporter/Ion Channel; Neuronal Signaling;Immunology/Inflammation儲存式: -20C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性數據體外實驗 H2O : 50 mg/mL (438.52 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concen

3、tration制備儲備液1 mM 8.7704 mL 43.8520 mL 87.7039 mL5 mM 1.7541 mL 8.7704 mL 17.5408 mL10 mM 0.8770 mL 4.3852 mL 8.7704 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性Tat-NR2B9c TFA (NA-1 TFA)由 20 個氨酸組成的多肽，為 PSD-95 的抑制劑，對 PSD-95d2 和 PSD-95d1的 EC50 值分別為 6.7 nM 和 670 nM 1。Tat-NR2B9c 同

4、時可降低 NMDA 誘導的 p38 的活化，抑制神經元型1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE氧化氮合酶/PSD-95 (nNOS/PSD-95) 的相互作，具有神經保護作 1 2。IC50 & Target EC50: 6.7 nM (PSD-95d2), 670 nM (PSD-95d1) 1NO synthase 1戶使本產品發表的科研獻 J Cereb Blood Flow Metab. 2018 Mar 7:271678X18762637. Sci Rep. 2018 May 18;8(1):7848.See more cu

5、stomer validations on HYPERLINK / www.MedChemEREFERENCES1. Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. JNeurosci. 2007 Sep 12;27(37):9901-15.2. Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntingtondisease. Neurobiol Dis. 2012 Mar;45(3):999-1009.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792