1、ONH3COOHCH3H3PO41 1/2H2O學習要求學習要求授課內容授課內容學習小學習小 結結重點難點重點難點ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONHNHOR1R2巴比妥類藥物基本結構OOONH3COOHCH3H3PO41 1/2H2O弱酸性 水解性 與金屬離子成鹽 ONH3COOHCH3H3PO41 1/2H2O巴比妥類藥物酸性比碳酸酸性弱，其鈉鹽水溶液不穩定，易吸收空氣中二氧化碳而析出

2、藥物，使溶液呈現渾濁。 NHNHOR1R2OONHNOHR1R2OONHNONaR1R2OONaOHH+ONH3COOHCH3H3PO41 1/2H2ONHNONaR1R2OOR1R2NHNH2OOR1R2ONaO+ Na2CO3 + NH3NaOHCO2H2OONH3COOHCH3H3PO41 1/2H2ONHNHOR1R2OONHNOAgR1R2OONNOAgR1R2NaOONNOAgR1R2AgOOAgNO3Na2CO3AgNO3ONH3COOHCH3H3PO41 1/2H2ONHNOR1R2OONHNOR1R2OOCuNNONH3COOHCH3H3PO41 1/2H2O化學名為5-乙基

3、-5-苯基-2,4,6(1H,3H,5H)-嘧啶三酮, 又名魯米那。NHHNOOOH3CONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONNR4OR1R2R3123456789123456ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2O化學名為1-甲基-5-苯基-7-氯-1,3-二氫-2H-1,4-苯并二氮雜 -2-酮，又名安定。 NNClOCH3ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONNClOCH3NHClCH3NOOHNHClCH3OH2

4、NOHO+H+H+OH-NClCH3ONH2OONH3COOHCH3H3PO41 1/2H2ONHNClOOHONH3COOHCH3H3PO41 1/2H2ONNClNNONH3COOHCH3H3PO41 1/2H2OCCl3OHHOOOH3CH3CONH2ONH2HNOOH3CNOCH3H3C水合氯醛甲丙氨酯格魯米特甲喹酮ONH3COOHCH3H3PO41 1/2H2ONNONCH3CH3CH3H3CNNNOOONNCH3NCl唑吡坦佐匹克隆ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONHHNOONHNHH3COOONOOCH3H3CCH3

5、HNOOH3CCH2CH3苯妥英撲米酮三甲雙酮乙琥胺ONH3COOHCH3H3PO41 1/2H2ONONH2H3COONaH3C卡馬西平丙戊酸鈉ONH3COOHCH3H3PO41 1/2H2O化學名為5,5-二苯基乙內酰脲鈉鹽，又名大倫丁鈉 。NHNOONaONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONHNONaO+ CO2 + H2ONHHNOO+ NaHCO3ONH3COOHCH3H3PO41 1/2H2ONHNONaOHNONH2OOHNH2OOH+ NH3NaOHONH3COOHCH3H3PO41 1/2H2ONONH2ONH3CO

6、OHCH3H3PO41 1/2H2OONaH3COCH3ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2O化學名為N,N-二甲基-2-氯-10H-吩噻嗪-10-丙胺鹽酸鹽，又名冬眠靈。 ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONSClRNSClRO+NSClROHOOONH3COOHCH3H3PO41 1/2H2OFONClOHONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H

7、3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2O化學名為17-甲基-3-羥基-4，5-環氧-7，8-二脫氫嗎啡喃-6-醇鹽酸鹽三水合物。 ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OOHONOHCH3HOOHONH3COHONOHCH3O偽嗎啡N-氧化嗎啡ONH3COOHCH3H3PO41 1/2H2OOHONOHCH3NHOOHH3CHNH3COO阿撲嗎啡鄰醌化合物（紅色）HClOONH3COOHCH3H3PO41 1/2

8、H2OC17H19NO3 K3Fe(CN)6C34H36N2O6 K4Fe(CN)6K4Fe(CN)6 FeCl3Fe4Fe(CN)63 KClONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2O化學名為1-甲基-4-苯基-4-哌啶甲酸乙酯鹽酸鹽，又名度冷丁。 ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONHOCH3CH3CH3CH3ONH3COOHCH3H

9、3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONNNNOCH3CH3CH3咖啡因NNNNHOCH3CH3茶堿HNNNNOCH3CH3可可堿ONH3COOHCH3H3PO41 1/2H2O化學名為1，3，7-甲基-3，7-二氫-1H-嘌呤-2，6-二酮一水合物，又名為咖啡堿。 ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2ONNNNH3COOCH3CH3-OOHOHONH3COOHCH3H3PO41 1/2H2ONNNNH3COOCH3CH3NHNNNH3COOCH3CH3O

10、HNHHNNNH3COCH3CH3NaOHCO2咖啡因咖啡啶ONH3COOHCH3H3PO41 1/2H2ONNOCH3CH3ONOCH3ONONH2O尼可剎米阿尼西坦吡拉西坦茴拉西坦尼可剎米吡拉西坦ONH3COOHCH3H3PO41 1/2H2ONONH2OONH3COOHCH3H3PO41 1/2H2ONH3CHOHOSSNCH3OHOHOONCH3CH3OCl吡硫醇甲氯芬酯ONH3COOHCH3H3PO41 1/2H2OONH3COOHCH3H3PO41 1/2H2O中樞神經中樞神經系統藥物系統藥物鎮靜催眠藥抗癲癇藥抗精神失常藥鎮痛藥中樞興奮藥ONH3COOHCH3H3PO41 1/2H2O鎮靜催眠藥鎮靜催眠藥巴比妥類苯二氮 類其他類基本結構、分類一般性質典型藥物構效關系發展、構效關系一般性質典型藥物弱酸性、水解性、與金屬離子成鹽反應苯巴比妥： 結構、性質、用途水解性地西泮：結構、性質、用途ONH3COOHCH3H3PO41 1/2H2O抗癲癇藥抗癲癇藥環內酰脲類二苯并氮 類脂肪酸類典型藥物苯妥英鈉：結構、性質、用途ONH3COOHCH3H3PO41 1/2H2O抗精神失常藥抗精神失常藥抗精神病藥抗抑郁藥典型藥物鹽酸氯丙嗪：結構、性質