有機合成研發基礎MSDS的學習和MSDS的延伸,新發藥業有限公司2016年3月19日,1. Whats MSDS,Material Safety Data Sheet (MSDS)材料安全數據表（卡）是一個包含某種物質相關數據的文檔。產品管理和工作場所的安全是其一個非常重要的組成部分。它的目的是提供給工人和緊急救護人員一個安全的方式或方法來處理這種物質。它也包含這種物質的一些其它信息，如一些物理和化學數據如熔點、沸點、閃點、毒性、對健康的影響、急救、反應、儲存、處置、防護設備、泄漏處理、燃爆性能。這份說明書的格式取決于它所在國家的相關規定。,What information is on the MSDS?,Product informationHazards Identification: data on flammability, reactivity, chronic hazards,.First-Aid Measures: description of recommended first-aid mesures in case an incident occurs, for example, in case of ingestion or inhalation of the substance, or in case of contact of the chemical product with eyes or skinFire Fighting Measures: recommended fire fighting apparatus, methods and products, flash point of the substance, fire-fighting class, upper and lower flammable limit (ULF - LFL), dangerous combustion products, recommendations for preventing explosions and firesAccidental Release Measures: mesures to be taken in case of the accidental release of the chemical substance or mixture into the environment: soil, rivers, waterways, sources of potable and non potable water, see, etc.Information on Recommanded Handling and Storage Conditions: recommended procedures for the handling, storage and usage of the chemical substance or mixtureExposure Controls / Personal Protection: this section often contains the exposure limits per country (classified by form of exposure or overexposure), as well as the personal protection equipment (PPE) recommended or required by law (respiratory protection, skin protection, eye protection, face mask, etc.),What information is on the MSDS?,Physical and Chemical Properties: product properties such as vapor pressure, vapor density, specific weight, water solubility, appearance, odor type, boiling point, pH value, viscosity, evaporation rate, freezing point,.Stability and Reactivity Data: information on the stability of the substance, conditions to avoid, incompatibility with other substances or materials, hazardous decomposition products, etc.Toxicological Information: information on the acute and chronic toxicity of the chemical substance, possibly data on the known carcinogenic properties, or labo testsEcological Information: information on the ecotoxicity of the chemical product, analysis of its components, biodegradability in different environments, etc.Disposal Considerations: this section often contains references to local legal requirements regarding the disposal of hazardous chemical productsTransport Information: shipping name, hazard class, UN number, package groupRegulatory Information: classification of the substance according to TSCA, SARA, CERCLA,., S- and R-PhrasesOther Information: this section often presents a list of abbreviations used in the MSDS, references to EU Directives en European or international (ISO) standards, version management of the MSDS, a disclaimer,.,How to get a compounds MSDS?,檢索渠道討論檢索不到具體化合物的MSDS怎么辦？回報給上司檢索類似官能團化合物,2. MSDS的延伸,穩定性的分析、確認化合物的穩定性分析重要性討論化合物穩定性的影響因素?熱、酸、堿、水、光（紫外光）、金屬或介質等設計穩定性驗證方案,2.1：常見熱穩定性差的化合物,熱分解、熱消除、熱聚合、熱重排等熱穩定性差的官能團討論？幾乎覆蓋所有官能團，甚至碳碳單鍵?；衔镒陨頍岱€定性差化合物在熱-水條件下穩定性差,化合物的熱穩定性影響反應結果,產品干燥過程（熱-水）導致的副反應，轉化率100%, 定量收率,2.2：化合物的酸穩定性,痕量酸導致化合物分解、消除、聚合、重排等熱穩定性差的官能團討論？可以異構或易于聚合的雙鍵、羥基尤其是導致產生可以重排的碳正離子、脫羧,化合物在痕量酸條件下的穩定性（如縮醛化合物）,產物蒸餾前，要檢測痕量酸和水份，兩者共存導致縮甲醛分解,2.3：化合物的堿穩定性,堿性甚至弱堿性條件下的聚合,2.4：光穩定性差的化合物,2.5：重結晶溶劑選擇不當導致的不穩定性,在進行乙醇重結晶時產生雜質,酯交換,尼莫地平的重結晶溶劑 貝尼地平,尼伐地平，用于治療高血壓，此外也有治療心絞痛和動脈硬化的效果,2.6：蒸餾（介質選擇不當或殘余