Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemECCR7Ligand1Cat.No.:HY-133073CASNo.:681514-83-0Synonyms:CCR7-Cmp2105分?式:C??H??N?O?S分?量:475.56作?靶點:CCR;LigandsforTargetProteinforPROTAC作?通路:GPCR/GProtein;Immunology/Inflammation;PROTAC儲存?式:-20°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性數據體外實驗DMSO:100mg/mL(210.28mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.1028mL10.5139mL21.0278mL5mM0.4206mL2.1028mL4.2056mL10mM0.2103mL1.0514mL2.1028mL請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(storedundernitrogen)。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。BIOLOGICALACTIVITY?物活性CCR7Ligand1(CCR7-Cmp2105)?CC趨化因?受體7(CCR7)的變構配體，也有效的CCR7拮抗劑，Kd值為3nM。CCR7Ligand1?種噻?唑-?氧化物配體，可抑制蛋?與CCL19激活反應結合，IC50為7.3μM。IC50&TargetHumanCCR71/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE3nM(Kd)體外研究CCR7Ligand1(CCR7-Cmp2105)bindstoapocketattheintracellularpartofCCR7betweentheendsofTM1,TM2,TM3,andTM6andtheloopbetweenTM7andH8[1].CCR7Ligand1allostericallyinhibitsbindingofthenativechemokineCCL19ligandinscintillationproximityassays(bottom)withanIC50of35nM[1].CCR7Ligand1(20,40,60,80,100μM)hasdose-dependentthermo-stabilizingeffectonCCR7[1].REFERENCES[1].JaegerK,etal.StructuralBasisforAllostericLigandRecognitionintheHumanCCChemokineReceptor7.Cell.2019Aug22;178(5):1222-1230.e10.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5895