Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESteroidsulfatase/17β-HSD1-IN-1Cat.No.:HY-151199分?式:C??H??N?O?S分?量:386.42作?靶點:Others作?通路:Others儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Steroidsulfatase/17β-HSD1-IN-1?種有效的類醇硫酸酯酶(steroidsulfatase)和17β-羥甾類醇脫氫酶1型(17β-HSD1)抑制劑，對胞內?類醇硫酸酯酶的IC50為28nM。Steroidsulfatase/17β-HSD1-IN-1可?于雌激素依賴性疾病的研究。IC50&TargetIC50:28nM(cellularhumansteroidsulfatase)[1]體外研究Steroidsulfatase/17β-HSD1-IN-1(compound13)(20μM;48h)hasalowcytotoxicityinHEK-293cells[1].Steroidsulfatase/17β-HSD1-IN-1(50-750nM;0-25min)caninhibitT47Dcellsgrowthand17β-HSD1inatime-dependentmanner[1].CellCytotoxicityAssay[1]CellLine:HEK-293cellsConcentration:20μMIncubationTime:48hResult:Exhibitedalowcytotoxicitywiththecellgrowthinhibitionof12.8%.CellProliferationAssay[1]CellLine:T47DConcentration:50,100,250,500and750nM1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEIncubationTime:0-25minResult:Inhibitedcellgrowthand17β-HSD1inatime-dependentmanner.體內研究Steroidsulfatase/17β-HSD1-IN-1showsgoodmetabolicstabilityinhumanhepaticS9fraction(t1/2=47min)andlowintrinsicclearanceClint(15μL/min/mgprotein)[1].REFERENCES[1].MohamedA,etal.DualTargetingofSteroidSulfataseand17β-HydroxysteroidDehydrogenaseType1byaNovelDrug-ProdrugApproach:APotentialTherapeuticOptionfortheTreatmentofEndometriosis.JMedChem.2022Aug22.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5895