1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESodium gualenateCat. No.: HY-B2191CAS No.: 6223-35-4Synonyms: Guaiazulenesulfonate sodium分式: CHNaOS分量: 300.35作靶點: Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數據體外實驗 DMSO : 30 mg/mL (

2、99.88 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.3294 mL 16.6472 mL 33.2945 mL5 mM 0.6659 mL 3.3294 mL 6.6589 mL10 mM 0.3329 mL 1.6647 mL 3.3294 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Sodium gualenate (Guaiazulenesulfonate sodiu

3、m)桂烯的親性衍物，具有優良的抗炎和愈傷作，主 于治療指腸潰瘍，胃潰瘍和胃炎。體外研究Sodium gualenate is an unstable compound, which is gradually decomposed in the solid state at roomtemperature. When heated, Sodium gualenate decomposes almost completely within 1 week. It was foundthat a kneaded mixture of Sodium gualenate and cornstarch (w

4、eight ratio; 1:250) for tableting with water is1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEstable. So, during production, Sodium gualenate could be stabilized using water 1. Sodium gualenateslightly inhibits the histamine release from rat peritoneal mast cells and strongly inhibits the leukocyt

5、eemigration induced by fMLP 2.體內研究 Sodium gualenate has been frequently used for the treatment of human gastritis. Cytoprotection is defined asthe main mechanism of Sodium gualenate to protect the mucosa of the stomach and the antipeptic actions invivo have also been shown 2.REFERENCES1. Nakamichi K

6、, et al. Stabilization of sodium guaiazulene sulfonate in granules for tableting prepared using a twin-screw extruder. Eur JPharm Biopharm. 2003 Nov;56(3):347-54.2. Cao T, et al. Synthesis and Biological Evaluation of 3, 8-dimethyl-5-isopropylazulene Derivatives as Anti-gastric Ulcer Agent. Chem BiolDrug Des. 2016 Aug;88(2):264-71.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: