1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECB30865Cat. No.: HY-14373CAS No.: 206275-15-2Synonyms: ZM 242421分式: CHBrNO分量: 516.39作靶點: Nampt作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 33.33 mg/mL (64.5

2、4 mM; Need ultrasonic)H2O : 0.1 mg/mL (insoluble)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.9365 mL 9.6826 mL 19.3652 mL5 mM 0.3873 mL 1.9365 mL 3.8730 mL10 mM 0.1937 mL 0.9683 mL 1.9365 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 CB30865(ZM 242421)是Nampt抑制劑。REFERE

3、NCES1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE1. Lockman JW, et al. Analogues of 4-(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino-N-(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt). J Med Chem. 2010 Dec23;53(24):87

4、34-8746.2. Fleischer TC, et al. Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound. Chem Biol. 2010Jun 25;17(6):659-664.3. Bavetsias V, et al. The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent. J MedChem.

5、 2002 Aug 15;45(17):3692-3702.4. Skelton LA, et al. Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitorICI 198583 with an undefined mechanism of action. Cytometry. 1998 Sep 1;33(1):56-66.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5