1、 從腫瘤標(biāo)志物淺談臨床科研從腫瘤標(biāo)志物淺談臨床科研九區(qū)：方申存九區(qū)：方申存1;.住院號(hào)住院號(hào)標(biāo)本標(biāo)本CEACEANSENSECY211CY211SCCSCCCA125CA125CA199CA199121098胸水24.52202.541.7212240.1血2.37.082.340.9584.890.1122055胸水0.4916.4384.250.81290.32.44血0.89.382.510.4447.243.99122166胸水6.597.393.280.9146.2111.26血4.148.6856.141.4934.526.55122069胸水2.214.6676.912.3780

2、45.76血3.032.542.10.36142.615.27124406胸水0.898.0817.461.685248.23血1.6811.262.20.5171.7410.61124406胸水0.898.0817.461.68314.26.52血1.6811.262.20.5171.7410.61 127435胸水0.647.7611.850.74165.93.53血0.778.181.030.5762.266.09121128胸水0.383.0913.312.1379.32.87血0.5210.491.670.4489.665.89132990胸水0.618.9120.692.61189

3、21.21血0.6313.521.230.53119.14.49132668胸水1.6623.7660.125.71508.20.6結(jié)核性胸膜炎患者胸水中腫瘤標(biāo)志物結(jié)核性胸膜炎患者胸水中腫瘤標(biāo)志物2;.矽肺血清中腫瘤標(biāo)志物矽肺血清中腫瘤標(biāo)志物 機(jī)制研究（動(dòng)物或細(xì)胞實(shí)驗(yàn)） 提出問題（TM 是否增高及意義）TM在矽肺血清中是否增高（矽肺與正常人比較）TM在矽肺增高的意義（TM與矽肺嚴(yán)重性的相關(guān)性分析） 個(gè)案病例分析 大樣本分析比較 反向論證 TM為何增高或來源分析？ 比較灌洗液與血清TM濃度肺活檢免疫組化 熒光免疫雙染3;.矽肺血清中腫瘤標(biāo)志物矽肺血清中腫瘤標(biāo)志物1.矽肺與正常人血清中矽肺與正常人

4、血清中TM比較比較4;.矽肺血清中腫瘤標(biāo)志物矽肺血清中腫瘤標(biāo)志物2.個(gè)案相關(guān)性研究（不同時(shí)期矽肺血清個(gè)案相關(guān)性研究（不同時(shí)期矽肺血清TM變化）變化）5;.矽肺血清中腫瘤標(biāo)志物矽肺血清中腫瘤標(biāo)志物3.大樣本相關(guān)性分析大樣本相關(guān)性分析6;.矽肺血清中腫瘤標(biāo)志物矽肺血清中腫瘤標(biāo)志物4.反向論證反向論證7;.矽肺血清中腫瘤標(biāo)志物矽肺血清中腫瘤標(biāo)志物5.血清中血清中TM的來源（比較灌洗液和血清中的來源（比較灌洗液和血清中TM差別）差別）8;.矽肺血清中腫瘤標(biāo)志物矽肺血清中腫瘤標(biāo)志物6.血清中血清中TM的來源（肺活檢組織免疫組化）的來源（肺活檢組織免疫組化）9;.矽肺血清中腫瘤標(biāo)志物矽肺血清中腫瘤標(biāo)志物7

5、.TM來源何種細(xì)胞（熒光免疫雙染）來源何種細(xì)胞（熒光免疫雙染）10;.住院號(hào)住院號(hào)標(biāo)本標(biāo)本CEACEANSENSECY211CY211SCCSCCCA125CA125CA199CA199121098胸水24.52202.541.7212240.1血2.37.082.340.9584.890.1122055胸水0.4916.4384.250.81290.32.44血0.89.382.510.4447.243.99122166胸水6.597.393.280.9146.2111.26血4.148.6856.141.4934.526.55122069胸水2.214.6676.912.378045.76

6、血3.032.542.10.36142.615.27124406胸水0.898.0817.461.685248.23血1.6811.262.20.5171.7410.61124406胸水0.898.0817.461.68314.26.52血1.6811.262.20.5171.7410.61 127435胸水0.647.7611.850.74165.93.53血0.778.181.030.5762.266.09121128胸水0.383.0913.312.1379.32.87血0.5210.491.670.4489.665.89132990胸水0.618.9120.692.6118921.21

7、血0.6313.521.230.53119.14.49132668胸水1.6623.7660.125.71508.20.6血2.8714.72.40.6377.721.61結(jié)核性胸膜炎患者胸水中腫瘤標(biāo)志物結(jié)核性胸膜炎患者胸水中腫瘤標(biāo)志物11;.結(jié)核性胸膜炎患者胸水中腫瘤標(biāo)志物結(jié)核性胸膜炎患者胸水中腫瘤標(biāo)志物姓名姓名住院號(hào)住院號(hào)標(biāo)本標(biāo)本CEACEANSENSECY211CY211SCCSCCCA125CA125CA199CA199袁小露126914治療前胸水0.383.0913.312.1379.32.87兩周后胸水0.272.885.81.52139.72.92三周后胸水0.4321.543.

8、431.4226.762.96王燕127435胸水0.647.7611.850.74165.93.53一周后胸水0.5117.459.690.43120.22.92劉翠英128540胸水1.132.2228.180.49861.70.6二周后胸水1.89.39.630.6774.2720.86抗結(jié)核治療前后胸水中抗結(jié)核治療前后胸水中TM變化變化12;.結(jié)核性胸膜炎患者胸水中腫瘤標(biāo)志物結(jié)核性胸膜炎患者胸水中腫瘤標(biāo)志物1.血清血清CA125與肺結(jié)核與肺結(jié)核The value of CA-125 in the evaluation of tuberculosis activity.Respir Me

9、d. 2001;95(8):666-9.13;.結(jié)核性胸膜炎患者胸水中腫瘤標(biāo)志物結(jié)核性胸膜炎患者胸水中腫瘤標(biāo)志物2.血清血清CA125與肺結(jié)核與肺結(jié)核Serum CA-125: biomarker of pulmonary tuberculosis activity and evaluation of response to treatment.Clin Invest Med. 2012;35(4):223-8.注：Group1:活動(dòng)性肺結(jié)核；Group2：非活動(dòng)性肺結(jié)核：Group3:正常人14;.結(jié)核性胸膜炎患者胸水中腫瘤標(biāo)志物結(jié)核性胸膜炎患者胸水中腫瘤標(biāo)志物3.血清血清CA125與肺結(jié)核與肺結(jié)核Serum CA-125: biomarker of pulmonary tuberculosis activity and evaluation of response to treatment.Clin Invest Med. 2