Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemERUSKI-201Cat.No.:HY-123781CASNo.:1458031-48-5分?式:C??H??N?OS分?量:357.51作?靶點(diǎn):Hedgehog作?通路:StemCell/Wnt儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(279.71mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.7971mL13.9856mL27.9712mL5mM0.5594mL2.7971mL5.5942mL10mM0.2797mL1.3986mL2.7971mL體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:2.5mg/mL(6.99mM);Clearsolution;NeedultrasonicBIOLOGICALACTIVITY?物活性RUSKI-201dihydrochloride?種有效且特異的Hedgehog酰轉(zhuǎn)移酶(Hhat)抑制劑，其IC50為0.20μM。RUSKI-201dihydrochloride能夠阻斷Shh過(guò)表達(dá)細(xì)胞的Hh信號(hào)，抑制Hh棕櫚酰化。RUSKI-2011/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEdihydrochloride?種有潛?的Hhat化學(xué)探針，可?于Hhat催化功能的研究[1]。REFERENCES[1].UrsulaRRodgers,etal.CharacterizationofHedgehogAcyltransferaseInhibitorsIdentifiesaSmallMoleculeProbeforHedgehogSignalingbyCancerCells.ACSChemBiol.2016Dec16;11(12):3256-3262.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-5