Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEAuriculinACat.No.:HY-P3765CASNo.:91421-87-3分?式:C???H???N??O??S?分?量:2542.81SequenceShortening:RSSCFGGRIDRIGAQSGLGCNSFR(Disulfidebridge:Cys4-Cys20)作?靶點:Others作?通路:Others儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性AuriculinA?種合成的?房利鈉因?(ANF)，具有?流動?學(xué)作?。AuriculinA拮抗?腎?管收縮，響兔后肢?流灌注壓、?率、全??壓的動脈壓?反射控制。體內(nèi)研究AuriculinA(0.3μg/min/kg;i.v.;for30min)antagonizesrenalvasoconstrictioninthedog[1].AuriculinA(2μg/kgprime,0.2μg/kg/min;i.v.;for45min)influencesonarterialbaroreflexcontrolofheartrate,systemicbloodpressure,andperfusionpressureinthehindlimb(perfusedatconstantflow)inrabbits[2].AnimalModel:Femalemongreldogsusedinearlyclampexperiments(15-20kg,anesthetizedwith30mg/kgpentobarbitalsodiumi.v.)[1]Dosage:0.3μg/min/kgAdministration:Intravenousinjection;lastfor30minResult:Increasedglomerularfiltrationrate(GFR)16±4%andNaexcretion(UNaV)261±63%,whereasitdecreasedurineosmolality(Uosm)36±7%withoutchangingfreewaterclearance.Alsoincreaseddiuresis(V)andkaliuresis(UKV).AnimalModel:NewZealandwhitemalerabbits(3-3.5kg,anesthetizedwith50mg/kgChloralose(HY-1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEB1020)and500mg/kgUrethane(HY-B1207)i.v.)[2]Dosage:0.5μg/kgprime,0.05μg/kg/min;2μg/kgprime,0.2μg/kg/min;4μg/kgprime,0.4μg/kg/min;8μg/kgprime,0.8μg/kg/minAdministration:Intravenousinjection;lastfor30-60minResult:Significantlyreducedmeanbloodpressureandincreasedmeanperfusionpressureat4μg/kgprime,0.4μg/kg/mindose,whileheartratedidnotchange.REFERENCES[1].SosaRE,etal.Relationshipbetweenrenalhemodynamicandnatriureticeffectsofatrialnatriureticfactor.AmJPhysiol.1986Mar;250(3Pt2):F520-4.[2].VolpeM,etal.Vagalmediationoftheeffectsofatrialnatriureticfactoronbloodpressureandarterialbaroreflexesintherabbit.CircRes.1987May;60(5):747-55.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.