Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEJNKInhibitorVIIICat.No.:HY-107598CASNo.:894804-07-0Synonyms:TCSJNK6o分?式:C??H??N?O?分?量:356.38作?靶點:JNK作?通路:MAPK/ERKPathway儲存?式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:250mg/mL(701.50mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.8060mL14.0300mL28.0599mL5mM0.5612mL2.8060mL5.6120mL10mM0.2806mL1.4030mL2.8060mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(5.84mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性JNKInhibitorVIII(TCSJNK6o)c-JunN-末端激酶(JNK-1,-2,-3)抑制劑，抑制JNK-1、JNK-2、JNK-3的Ki值分別為2nM、4nM、52nM，對JNK-1、JNK-2的IC50值分別45nM和160nM[1]。IC50&TargetJNK1JNK1JNK2JNK22nM(Ki)45nM(IC50)4nM(Ki)160nM(IC50)JNK352nM(Ki)體外研究JNKInhibitorVIII(TCSJNK6o)showsover1000-foldselectiveforJNK-1and-2overotherMAPkinasesincludingERK2,p38α,andp38δ[1].戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?LifeSci.2020Sep1;256:117955.?MicrovascRes.2022Feb9;141:104338.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].SzczepankiewiczBG,etal.Aminopyridine-basedc-JunN-terminalkinaseinhibitorswithcellularactivityandminimalcross-kinaseactivity.JMedChem.2006Jun15;49(12):3563-80.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;0