Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEAntitumoragent-75Cat.No.:HY-151295分?式:C??H??FN?分?量:438.5作?靶點(diǎn):Others作?通路:Others儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Antitumoragent-75?種新型有效的抗腫瘤劑。Antitumoragent-75對癌癥和正常?類細(xì)胞系具有細(xì)胞毒性作?。Antitumoragent-75與Antitumoragent-74(HY-151292)結(jié)合使?時(shí)對?肺腺癌（細(xì)胞系A(chǔ)549）具有?度選擇性的細(xì)胞毒作?，其IC50值為2.8μM。Antitumoragent-75可?于癌癥的研究。IC50&TargetIC50:2.8μM(A549cells)[1]體外研究Antitumoragent-75(14da)showsahighlyselectivecytotoxiceffect(combinedwith13da,mrBIQ13da/14da)againsthumanlungadenocarcinoma(celllineA549)withanIC50valueof2.8μM[1].Antitumoragent-75(1,5,25,50,100μM;0-48h)(mriBIQ13da/14da)hasthecytotoxiceffectinA549cells[1].Antitumoragent-75(1,2.5,and5μM;12h)(mriBIQ13da/14da)hasthemechanismofthecytotoxiceffectonA549cellsmaybeassociatedwiththestoppingofthecellcycleinphaseSandinhibitionofDNAsynthesisaswellaswiththeinductionofmithochondrialapoptosis[1].Antitumoragent-75(1,2.5and5μM)increasestheproductionofreactiveoxygenspecies(ROS)andinducesmitochondrialapoptosisinA549cells.CellCytotoxicityAssay[1]CellLine:sevencancercelllinesandWI38(theNormalHumanFetalLungFibroblastline)Concentration:1-100μMIncubationTime:Result:Exhibitedgreateractivityagainstmostofthecancerlinesandnormalhumancelllines.1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemECellProliferationAssay[1]CellLine:A549CellConcentration:1,5,25,50,100μMIncubationTime:0-48hResult:LeadtoasharpdecreasethepresenceofmriBIQ13da/14daatconcentrationsclosetotheIC50valuesintherateofcelldivision.CellCycleAnalysis[1]CellLine:A549cellsConcentration:1,2.5,and5μMIncubationTime:12hResult:IncreasedthenumberofcellsintheS-phasewithmnBIQ13da/14daatconcentrationsof1,2.5,and5μMat49.0%,66.3%,and68.0%,respectively.ApoptosisAnalysis[1]CellLine:A549cellsConcentration:1,2.5and5μMIncubationTime:Result:(mrBIQ13da/14da)InducedmitochondrialapoptosisinA549cells.REFERENCES[1].VakhidA.Mamedov,etal.SynthesisofMorpholine?,Piperidine?,andN?SubstitutedPiperazine-Coupled2?(Benzimidazol-2-yl)-3-arylquinoxalinesasMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresea