1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAstramembrangeninCat. No.: HY-N1485CAS No.: 78574-94-4Synonyms: Cyclosieversigenin分式: CHO分量: 490.72作靶點(diǎn): Apoptosis作通路: Apoptosis儲(chǔ)存式: Please store the product under the recommended conditions inthe COA.BIOLOGICAL ACTIVITY物活性 Astra

2、membrangenin 環(huán)芪醇 種三萜皂苷化合物，是黃芪 (Astragalus membranaceus (Fisch.) Bunge)中活性成分的解產(chǎn)物。Astramembrangenin 具有服安全性，具有泛的藥理學(xué)作，包括端粒酶活化，端粒延長，抗炎和抗氧化特性。Astramembrangenin 具有抗衰特性，CAG 刺激新質(zhì)形成細(xì)胞和神經(jīng)細(xì)胞中的端粒酶活性，并誘導(dǎo) CREB 活化。 Astramembrangenin 可能在抑郁癥中具有新的治療作。體外研究Astramembrangenin (0-10 M; 3-6 days) increases cell growth compa

3、red to the vehicle control in HEKcultures 1.Astramembrangenin (0.3 M; 5-90 mins) induces CREB phosphorylation in primary corticalneurons, total CREB expression is unaltered by CAG in both cell type 1.Astramembrangenin (3 M; 6-48hours) may promotes prosurvival signaling in neurons, increases tert mRN

4、A expression, exhibits increasedbcl2 mRNA expression 1.Cell Viability Assay 1Cell Line: HEK cellsConcentration: 1 M, 3 M, 10 MIncubation Time: 3-6 daysResult: Doubled the cell growth at 6 days.Western Blot Analysis 11/2 Master of Small Molecules 您邊的抑制劑師www.MedChemECell Line: Neuronal cellsConcentrat

5、ion: 0.3 MIncubation Time: 5 mins, 15 mins, 30 mins, 90 minsResult: Suggested that CAG induces CREB activation in neuronal cells.RT-PCR 1Cell Line: Neuronal cellsConcentration: 3 MIncubation Time: 6-48 hoursResult: Increased tert, bcl2 mRNA expression.REFERENCES1. Ip FC, et al. Cycloastragenol is a

6、potent telomerase activator in neuronal cells: implications for depression management. Neurosignals.2014;22(1):52-63.2. Yu Y, et al. Cycloastragenol: An exciting novel candidate for age-associated diseases. Exp Ther Med. 2018 Sep;16(3):2175-2182.3. Sun C, et al. Cycloastragenol mediates activation and proliferation suppression in concanavalin A-induced mouse lymphocyte pan-activation model. Immunopharmacol Immunotoxicol. 2017 Jun;39(3):131-139.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only