1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBenorilateCat. No.: HY-107795CAS No.: 5003-48-5Synonyms: Salipran分式: CHNO分量: 313.3作靶點: Prostaglandin Receptor作通路: GPCR/G Protein儲存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性數據體外實驗

2、 DMSO : 125 mg/mL (398.98 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.1918 mL 15.9591 mL 31.9183 mL5 mM 0.6384 mL 3.1918 mL 6.3837 mL10 mM 0.3192 mL 1.5959 mL 3.1918 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗 請根據您的實驗動物和給藥式選擇適當的溶解案，配制前請先配制澄清的儲備液，再依次添加助溶劑(為保證實驗結果的可

3、靠性，體內實驗的作液，建議您現現配，當天使；澄清的儲備液可以根據儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.64 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (6.64 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% cor

4、n oilSolubility: 2.08 mg/mL (6.64 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Benorilate對酰氨 酚和酰楊酸的酯化產物，具有抗炎、鎮痛、解熱的作。Benorilate還能夠抑制前列腺素 (PG) 的合成。IC50 & Target Prostaglandin 4.體外研究 Benorilate is an esterified aspirin preparation whose antirheumatic prope

5、rties are reported to be as good asthose of aspirin 1.Benorylate causes a large decrease in the livers conversion rate of lactate into glucose, an importantcomponent of glucose homeostasis. Benorylate also impairs the urea synthesis rate from ammonia, anotherimportant function of the liver 2.體內研究 Be

6、norylate is probably absorbed as the intact molecule which accounts for its good gastric tolerance 3.Benorylate could inhibit PG synthesis in laboratory animals and in human tissue 4.REFERENCES1. Croft DN, et al. Gastric bleeding and benorylate, a new aspirin. Br Med J. 1972 Sep 2;3(5826):545-7.2. C

7、astell JV, et al. Effects of benorylate and impacina on the metabolism of cultured hepatocytes. Xenobiotica. 1985 Aug-Sep;15(8-9):743-9.3. Wright V, et al. A review of benorylate - a new antirheumatic drug. Scand J Rheumatol Suppl. 1975;13:5-8.4. A. Bennett , et al. Inhibition of Prostaglandin Synthesis by Benorylate. Rheumatology, Volume XII, Issue suppl, 1 January 1973, Pages101-105.McePdfHeightCaution: Product has not been fully validated for medical applications.For resea