Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEARGX-119Cat.No.:HY-P991066CASNo.:2966023-63-0作?靶點:nAChR作?通路:MembraneTransporter/IonChannel;NeuronalSignaling儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性ARGX-119?種針對肌?特異性激酶（MuSK）特異的?流?化激動劑單克隆抗體。ARGX-119可?于神經(jīng)肌?疾病的研究。ARGX-119的同型對照可參考HumanIgG1lambda1,IsotypeControl(HY-P99992)。體外研究ARGX-119bindswithhighaffinitytotheFrizzled-likedomainofhuman,nonhumanprimate,rat,andmouseMuSK,withoutoff-targetbinding,makingitsuitableforclinicaldevelopment.WithintheFcregion,ARGX-119harborsL234AandL235Amutationstodiminishpotentialimmune-activatingeffectorfunctions.ItsmodeofactionistoactivateMuSK,withoutinterferingwithitsnaturalligandneuralAgrin,andclusteracetylcholinereceptorsinadose-dependentmanner,therebystabilizingneuromuscularfunction[1].體內(nèi)研究InamousemodelofDOK7congenitalmyasthenia(CM),ARGX-119(20mg/kg)preventsearlypostnatallethalityandreversesdiseaserelapseinadultDok7CMmicebyrestoringneuromuscularfunctionandreducingmuscleweaknessandfatigabilityinadose-dependentmanner[1].REFERENCES[1].VanhauwaertR,etal.ARGX-119isanagonistantibodyforhumanMuSKthatreversesdiseaserelapseinamousemodelofcongenitalmyasthenicsyndrome.SciTranslMed.2024Sep18;16(765):eado7189.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792