DegenerationACUTECELLULARSWELLINGSectionB2021/5/712021/5/722021/5/73Excessiveentryoffreefattyacidsintotheliver(starvation,corticosteroidtherapy).Enhancedfattyacidsynthesis.Decreasedfattyacidoxidation.Increasedesterificationoffattyacidtotriglycerides(alcohol).Decreasedapoproteinsynthesis(CCl4).Impairedlipoproteinsecretionfromtheliver(alcohol).FATTYCHANGE2021/5/74MorphologyoffattychangeSudanIII,OilredO,OsmicacidLiverHeartKidney2021/5/752021/5/762021/5/77IntracellularhyalinechangesHyalinedegenerationofarteriolesHyalinedegenerationofconnectivetissueHyalinechanges(degeneration)2021/5/78Absorptionofproteincausinghyalinedropletsinproximalepithelialcellsinthekidney.Russelbodiesinplasmacells.Viralinclusionsinthecytoplasmorthenucleus.Massesofalteredintermediatefilaments(Mallorybodies).Intracellularhyalinechanges2021/5/792021/5/7109、人的價值，在招收誘惑的一瞬間被決定。2023/2/32023/2/3Friday,February3,202310、低頭要有勇氣，抬頭要有低氣。2023/2/32023/2/32023/2/32/3/20234:35:30PM11、人總是珍惜為得到。2023/2/32023/2/32023/2/3Feb-2303-Feb-2312、人亂于心，不寬余請。2023/2/32023/2/32023/2/3Friday,February3,202313、生氣是拿別人做錯的事來懲罰自己。2023/2/32023/2/32023/2/32023/2/32/3/202314、抱最大的希望，作最大的努力。03二月20232023/2/32023/2/32023/2/315、一個人炫耀什么，說明他內心缺少什么。。二月232023/2/32023/2/32023/2/32/3/202316、業余生活要有意義，不要越軌。2023/2/32023/2/303February202317、一個人即使已登上頂峰，也仍要自強不息。2023/2/32023/2/32023/2/32023/2/32021/5/7112021/5/7122021/5/7132021/5/714Aheterogeneousgroupofpathogenicfibrillarproteinsaccumulatingintissuesandorgans.ExcesssynthesisResistancetocatabolismAMYLOIDOSIS2021/5/715ChemicalnatureofamyloidfibrilsTwomajorforms:AL(amyloidlightchainprotein)AA(amyloid-associatedprotein):

DerivedfromserumAA(12kd)synthesizedinliverandelevatedininflammatorystates.2021/5/716Minorformsofamyloidfibrils:Transthyretin(TTR):Amutantformofaserumproteininfamilialamyloidpolyneuropathy.AvariantofTTRinaging.Beta-2-microglobulin(thecomponentofclassIMHCmolecules)inlong-termhemidialysis.2021/5/717Minorformsofamyloidfibrils:

Beta-2-amyloidproteinformsthecoreofcerebralplaquesanddepositswithincerebralvesselwallsinAlzheimerdisease,derivingfromatransmembraneglycoproteinprecursor.2021/5/718Minorformsofamyloidfibrils:Transthyretin(TTR):Amutantformofaserumproteininfamilialamyloidpolyneuropathy.AvariantofTTRinaging.Beta-2-microglobulin(thecomponentofclassIMHCmolecules)inlong-termhemidialysis.2021/5/719Minorformsofamyloidfibrils:

Beta-2-amyloidproteinformsthecoreofcerebralplaquesanddepositswithincerebralvesselwallsinAlzheimerdisease,derivingfromatransmembraneglycoproteinprecursor.2021/5/720primary(B-celldyscrasia,AL)Secondaryorreactive(AA):Collagendiseases,bronchiectasis,chronicosteomyelitis.Hemodialysis-related:Beta-2-microglobulindeposition.Hereditary(AA)ClinicalformsofamyloidosisSystemicamyloidosis:2021/5/721Nodular(tumor-formingdeposits,B-celldyscrasia,AL)Endocrineamyloidosis(procalcitonin)Amyloidosisofaging:Heart,lung,pancreas,spleen,brain.Localizedamyloidosis2021/5/7222021/5/723

Exogenous:

CarbonTattooingEndogenous:LipofuscinMelaninHemosiderinBilirubinPigmentation2021/5/7242021/5/7252021/5/7262021/5/7272021/5/7282021/5/729DystrophiccalcificationMetastaticcalcificationPathologiccalcification2021/5/730NecrotictissuesAtheromaDamagedheartvalvesDystrophiccalcification2021/5/731Fig2-132021/5/7322021/5/733IncreasedsecretionofparathyroidhormoneDestructionofbonetissueVitaminD-relateddisorders:SarcoidosisRenalfailureMetastaticcalcificationHypercalcimia2021/5/734MetastaticcalcificationAffectingInterstitialtissueofgastricmucosaKidneysLungsPulmonaryveinsSystemicarteries2021/5/7359、人的價值，在招收誘惑的一瞬間被決定。03-2月-2303-2月-23Friday,February3,202310、低頭要有勇氣，抬頭要有低氣。***2/3/20234:35:30PM11、人總是珍惜為得到。03-2月-23**Feb-2303-Feb-2312、人亂于心，不寬余請。***Friday,February3,202313、生氣是拿別人做錯