維生素D與男性不育癥的相關研究贛州市人民醫院泌尿外科鄧小林

一、概述：男性不育一、VD來源及代謝EurJEndocrinol.2012May;166(5):765-78.VitaminDandfertility:asystematicreview.NatRevEndocrinol.2014Mar;10(3):175-86.VitaminDandmalereproduction二、VD功能EurJEndocrinol.2012May;166(5):765-78.VitaminDandfertility:asystematicreview.VitaminDAndrogenstatusSemenTesticulopathyPositiveassociationofandrogenswith

25(OH)DlevelsConcordantseasonalvariationof

testosteroneand25(OH)DLowvitaminDstatusisassociatedwith

secondaryandcompensated

hypogonadismVitaminDtreatmentmightincrease

testosteronelevelsPositiveassociationofvitaminD

statuswithsemenquality(motility,morphology)1,25(OH)2D3increasessperm

motilityandinducesacrosomereaction

invivoAssociatedwithlow

CYP2R1expressionandlow25(OH)DlevelsTesticulopathicmenshow

osteoporosisandosteopenia

includingalteredbonemarkerlevels

andbonemineraldensitydespite

normaltestosteronelevels

三、VD與男性生殖EurJEndocrinol.2012May;166(5):765-78.VitaminDandfertility:asystematicreview.（一）VDR及代謝酶的表達

VDR在精子頭部、頸部高表達VDR精子中段、尾部部無表達JAnat.2008Nov;213(5):555-64.Humanspermanatomy:ultrastructurallocalizationof1alpha,25-dihydroxyvitaminDreceptoranditspossibleroleinthehumanmalegamete（一）VDR及代謝酶的表達

2010May;25(5),HumanReproduction:VitaminDreceptorandvitaminDmetabolizingenzymesareexpressedinthehumanmalereproductivetract睪丸前列腺（一）VDR及代謝酶的表達差異正常組對照組CYP24A1的表達2010May;25(5),HumanReproduction:VitaminDreceptorandvitaminDmetabolizingenzymesareexpressedinthehumanmalereproductivetract（二）調節精子代謝

調節精子蛋白酪氨酸和蘇氨酸磷酸化調節精子膽固醇外流，參與獲能JAnat.2008Nov;213(5):555-64.Humanspermanatomy:ultrastructurallocalizationof1alpha,25-dihydroxyvitaminDreceptoranditspossibleroleinthehumanmalegamete（二）調節精子蛋白磷酸化酪氨酸磷酸化蘇氨酸磷酸化JAnat.2008Nov;213(5):555-64.Humanspermanatomy:ultrastructurallocalizationof1alpha,25-dihydroxyvitaminDreceptoranditspossibleroleinthehumanmalegamete（三）VD與精子存活JAnat.2008Nov;213(5):555-64.Humanspermanatomy:ultrastructurallocalizationof1alpha,25-dihydroxyvitaminDreceptoranditspossibleroleinthehumanmalegamete（四）VD與精液參數VitaminDispositivelyassociatedwithspermmotilityandincreasesintracellularcalciuminhumanspermatozoa.Humanreproduction,2011.26(6):p.1307-1317（四）VD與精液參數精子活力前向運動精子比率正常精子形態比例VitaminDispositivelyassociatedwithspermmotilityandincreasesintracellularcalciuminhumanspermatozoa.Humanreproduction,2011.26(6):p.1307-1317（五）VD調節精子Ca2+濃度VitaminDispositivelyassociatedwithspermmotilityandincreasesintracellularcalciuminhumanspermatozoa.Humanreproduction,2011.26(6):p.1307-1317（五）VD調節精子Ca2+濃度VitaminDispositivelyassociatedwithspermmotilityandincreasesintracellularcalciuminhumanspermatozoa.Humanreproduction,2011.26(6):p.1307-1317調節網絡（五）VD調節精子Ca2+濃度（六）調節頂體反應VitaminDispositivelyassociatedwithspermmotilityandincreasesintracellularcalciuminhumanspermatozoa.Humanreproduction,2011.26(6):p.1307-1317（七）與睪酮的季節性

25(OH)VD睪酮游離睪酮指數ClinEndocrinol(Oxf).2010Aug;73(2):243-8.AssociationofvitaminDstatuswithserumandrogenlevelsinmen（七）與睪酮的季節性ClinEndocrinol(Oxf).2010Aug;73(2):243-8.AssociationofvitaminDstatuswithserumandrogenlevelsinmen（八）流行病學FertilSteril.2011Mar1;95(3):1000-4.AreserumlevelsofvitaminDassociatedwithsemenquality?Resultsfromacross-sectionalstudyinyounghealthy