1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPIM-447 dihydrochlorideCat. No.: HY-19322BCAS No.: 1820565-69-2Synonyms: LGH447 dihydrochloride分式: CHClFNO分量: 513.38作靶點: Pim作通路: JAK/STAT Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數據體外實驗 D

2、MSO : 46.7 mg/mL (90.97 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.9479 mL 9.7394 mL 19.4787 mL5 mM 0.3896 mL 1.9479 mL 3.8957 mL10 mM 0.1948 mL 0.9739 mL 1.9479 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 PIM447是泛PIM激酶抑制劑

3、，對PIM1，PIM2，PIM3的 Ki 分別為6，18，9 nM。戶使本產品發表的科研獻1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE Mol Cancer Ther. 2018 Apr;17(4):849-857.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Pano T et al. The novel pan-PIM kinase inhibitor, PIM447, displays dual anti-myeloma and bone p

4、rotective effects, and potentlysynergizes with current standards of care. Clin Cancer Res. 2016 Jul 20.2. Burger MT et al. Identification of N-(4-(1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide(PIM447), a Potent and Selective Proviral Insertion Site of

5、 Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials forHematological Malignancies. J Med Chem. 2015 Nov 12;58(21):8373-86.3. Peters TL et al. Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity toinhibition by PIM447.Oncotarget. 2016 Aug 20McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0