1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEalpha-AsaroneCat. No.: HY-N0700CAS No.: 2883-98-9Synonyms: -Asarone; trans-Asarone分式: CHO分量: 208.25作靶點: GABA Receptor作通路: Membrane Transporter/Ion Channel; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 mo

2、nths-20C 1 month溶解性數據體外實驗 DMSO : 100 mg/mL (480.19 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (12.00 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (12.00 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedC

3、hemE3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (12.00 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 alpha-Asarone (-Asarone)是菖蒲屬中主要的活性物質，具有抗抑等功效。體外研究 The results indicated that -asarone significantly attenuated the LPS-stimulated increase inneuroinflammatory responses and suppressed pro-in

4、flammatory cytokine production in BV-2 cells.Mechanistic study revealed that alpha-Asarone (-Asarone) inhibited the LPS-stimulated activation viaregulation of nuclear factor kappa-B by blocking degradation of inhibitor kappa B-alpha signaling in BV-2microglial cells 2.體內研究 The present results reveal

5、 that the acute treatment of alpha-Asarone (-Asarone) elicited biphasic responseson immobility such that the duration of the immobility time is significantly reduced at lower doses (15 and 20mg/kg, i.p.) but increased at higher doses (50 and 100 mg/kg, i.p.) in the TST. Besides, alpha-Asarone (-Asar

6、one) at higher doses (50 and 100 mg/kg, i.p.) significantly decreased the spontaneous locomotor activity1.REFERENCES1. Ranjithkumar Chellian, et al. Biphasic Effects of -Asarone on Immobility in the Tail Suspension Test: Evidence for the Involvement ofthe Noradrenergic and Serotonergic Systems in It

7、s Antidepressant-Like Activity. Front Pharmacol. 2016; 7: 72.2. Byung-Wook Kim, et al. -Asarone attenuates microglia-mediated neuroinflammation by inhibiting NF kappa B activation and mitigatesMPTP-induced behavioral deficits in a mouse model of Parkinsons disease. Neuropharmacology, Volume 97, October 2015, Pages 46573. Hye-Jung Park, et al. Effect of -asarone on angiogenesis and matrix metalloproteinase. Environmental Toxicology and Pharmacology,Volume 39, Issue 3, May 2015, Pages 11071114McePdfHeightCaution: Product has not been fully validated for medical applications.For