1、BioMEMS (生醫微機電)(3 units)Couse number: 6781Instructor: Gou-Jen WangClass hours: 1, 234Class level: GraduateClassroom: Mechanical Engineering Build. P427 Objects1. To give graduate students an in-depth understanding of standard microfabrication techniques used in the construction of biomedical microsy

2、stems.2. To enable the graduate students to know the major classes, components, and applications of biomedical microsystems and to demonstrate an understanding of the fundamental principles behind the operation of these systems.3. To prepare graduate students to apply knowledge of microfabrication t

3、echniques and applications to the design and manufacturing of a biomedical microdevice.Lecture SchedulesWeekTopics1l Review of biosystem2l Introduction of bio NEMS/MEMS3l Microfludics-Theoretical aspects (I)Fludics and Flows, Transport processes, System Design, An applicationBiological Fluids4l Micr

4、ofludics-Theoretical aspects (II)Fludics and Flows, Transport processes, System Design, An application Biological Fluids5l MicrofludicsComponents (I)Valves and Pumps , Injecting, Dosing, and Metering, Temperature measurement in Microfludic Systems, Optical Sensors, Electrochemical Sensors6l Microflu

5、dicsComponents (II)Valves and Pumps , Injecting, Dosing, and Metering, Temperature measurement in Microfludic Systems, Optical Sensors, Electrochemical Sensors7l Silicon and Cleanroom Processing (I)Substrate Fabrication, Optical Lithography, Additive Techniques, Substractive Techniques8l Silicon and

6、 Cleanroom Processing (II)Substrate Fabrication, Optical Lithography, Additive Techniques, Substractive Techniques9l Silicon and Cleanroom Processing (III)Substrate Fabrication, Optical Lithography, Additive Techniques, Substractive Techniques10l Mid-term Examination11l Polymer Micromachining (I)Thi

7、ck Resist Lithography, Ploymeric Surface Micromaching, Soft Lithography, Micromolding, Laser Micromachining , An Application-Microvessel Scafold for Tissue Enigineering12l Polymer Micromachining (I)Thick Resist Lithography, Ploymeric Surface Micromaching, Soft Lithography, Micromolding, Laser Microm

8、achining , An Application-Microvessel Scafold for Tissue Enigineering13l Glass Micromachining (I)Wet Chemical Etching, Reactive Ion Etching (RIE) of Glass, Laser Patterning, Powder Blasting, Glass Bonding, A Microfabrication ExampleCapillary Electrophoresis14l Glass MicromachiningWet Chemical Etchin

9、g, Reactive Ion Etching (RIE) of Glass, Laser Patterning, Powder Blasting, Glass Bonding, A Microfabrication ExampleCapillary Electrophoresis (II)15l Microfludics for Life Sciences and Chemistry (I)Microfilter, Microneedles, Micromixers, Microreactors, Microdispensers, Microseprators, CD Fludics16l

10、Microfludics for Life Sciences and Chemistry (II)Microfilter, Microneedles, Micromixers, Microreactors, Microdispensers, Microseprators, CD Fludics17l Microfludics for Life Sciences and Chemistry (III)Microfilter, Microneedles, Micromixers, Microreactors, Microdispensers, Microseprators, CD Fludics1

11、8l Final ExaminationGrading:1. Home Work (25%)2. Midterm Examination (40%) 3. Final Project(a)Oral Presentation (10%)(b)Writing (25%)Textbook： 1. Oliver Geschke et al., Microsystem Engineering of Lab-on-a-Chip Devices, 2004, Wiley-Vch (全華圖書代理) Tel: (04)2261-84852. Nam-Trung Nguyen and Steven T. Were

12、ley, Fundamentals and Application of Microfludics, 2002, Artech House Publishers.3. Class handoutReferences:1.Marc Madou, Fundamentals of Microfabrication, 2002, CRC Press.2.Tai-Ran Hsu, MEMS & MICROSYSTEMS Design and Manufacture, 2002, McGraw Hill.Instructor: Professor Gou-Jen Wang 王國禎 Room 320

13、, Mechanical Engineering BuildingTel : 2284-0725 ext. 320Eamil: .twRemarks:1. A sigle page A-4 hand-writing brief note is allowed for any examination. 2. Home work that is not turned in on schedule is scorelesss. 3. Course webpage: .tw/neural/Xploere.htmFinal

14、 Project 內容與格式修習本課程同學應於2007/12/14前草擬一頁左右之綱要(不含封面)，與教師討論所欲進行之專題方向，該綱要應簡略說明選擇該主題之動機並明列該專題之主要內容為何，以及參考資料，該主題經教師認可後即應針對專題之主題收集3篇以上與主題相關之文章、研究報告或技術報告，經研讀吸收整理後(即下列之第5項)，然後提出自己的心得與看法(即下列之第6項)，撰寫成專題報告，於學期結束前舉行專題報告時(以Powerpoint方式進行) 與Powerpoint檔案一併繳交，Powerpoint檔案將置於微系統類神經網路實驗室網站。專題報告內容應包括下列項目：(1) 封面：應列出課程名稱、

15、專題名稱、學生姓名及學號、授課老師及報告完成日期。(2) 目錄：可包含章節目錄以及圖表目錄。(3) 摘要：重點摘錄本報告之主題、內容以及成果或發現，以300至500字為宜。(4) 緣起（或是前言、緒論、引言等）：描述選擇該主題之動機，該主題之主要內容為何，過去有哪些相關之研究與討論，以及本報告之內容。(5) A. 相關之研究討論、方法或技術之介紹與說明：此部份可依主題內容分為數個章節撰寫。 B. 新方法：自行發展之新方法(6) 結論(結果)與討論：這些研究、方法或技術之總結，討論這些研究、方法或技術是否完整，尚有哪些問題待克服，未來可朝哪些方向去發展，預期要如何進行，並討論預期會遇到哪些困難與

16、可能的克服方法，若有自行研究或應用之成果更佳。(6) 參考資料：參考資料撰寫方式需一致，其格式參考下節所述。(7) 致謝（如有必要的話）。(8) 附錄。報告一律撰寫於A4格式紙張，上下左右邊距為2.54公分，封面不編頁，目錄以大寫羅馬字母（I, II 等）編頁，本文則以阿拉伯數字編頁，頁碼一律編於各頁頁尾中央。報告字體採用12 pt.、1.5倍行距，在本文中引用之參考資料應寫出其編排順序或是作者之姓氏與出版年份，被引用之參考資料應依其被引用順序或是依作者之姓氏依序列出，沒被引用之參考資料不應包含在參考資料中。參考資料之撰寫格式如下：(1) 文章：應依作者、文章全名（文章名稱以引號 “ 及 ” 或 標示之）、刊物或雜誌全名（刊物名稱以斜體字或加底線標示之）、刊物出版日期（包括卷號、期號、出版月份及年份）、文章頁碼。(2) 研究報告、技術報告或專書：應依作者、該報告或書全名（報告名稱或書名以斜體字或加底線標示之）、出版年份、出版商，如為專書之章節應加註章節數。參考資料撰寫格式舉例說明如下：1 洪榮哲，1994，最尖端的HSC工具機，機械技術雜誌，116期，74-81頁(中文期刊)。2 The National Techno