Primaryintracranialtumor:

Glioma膠質瘤（40%）Meningioma腦膜瘤（15%）Acousticneurinoma聽神經瘤（8%）Metastatictumors:lung,breast

§6Tumors分類發病率children:glioma,medulloblastoma

髓母細胞瘤醫學課件園Primaryintracranialtumor:§61Size,location>natureLocaleffectGeneraleffect特點影響Biologic~histologicmalignancyInvasionMetastasistumor醫學課件園Size,location>nature特點影響2Differentiation分化ClinicalprogressionGeneticchangesI.Astrocytoma星形細胞瘤AstrocytomaAnaplasticastrocytoma間變性-Glioblastomamultiforme多形性膠質母細胞瘤醫學課件園I.AstrocytomaAstrocytoma醫學課件3atypia,mitoticrate,capillary,endothelialcells,necrosis,hemorrhageAstrocytomaAnaplasticastrocytomaGlioblastomamultiformepoorlydefinedgray-whitesolidmultiform多形性:cyst,necrosis,hemorrhageAstrocytona病變醫學課件園atypia,mitoticrate,Astrocyto4P53

mutation/lossofchr.17pLossofchr.22qRb

mutation/lossofchr.13qP16deletion/lossofchr.3pLossofchr.19qLossofch.10EGFRgeneamplificationGeneticchangesinastrocytomaNormalastrocyteAstrocytomaAnaplasticastrocytomaGlioblaxtomamultiforme醫學課件園P53mutation/lossofchr.175astrocytoma醫學課件園astrocytoma醫學課件園6醫學課件園醫學課件園7Astrocytoma醫學課件園Astrocytoma醫學課件園www.yxkjy.co8Glioblatonamultiforme醫學課件園Glioblatonamultiforme醫學課件園ww9Giantcellsinglioblastomamultiforme醫學課件園Giantcellsinglioblastomamu10Giantcellsinglioblastomamultiforme醫學課件園Giantcellsinglioblastomamu11Giantcellsinglioblastomamultiforme,IHGFAP醫學課件園Giantcellsinglioblastomamu12Pseudopalisading(glioblastomamultiforme)醫學課件園Pseudopalisading(glioblastoma13Endothelialcellproliferationglioblastomamultiforme醫學課件園Endothelialcellproliferation14<20yCerebellumPrimitiveundifferentiatedcellsmalltumorcells,scantycytoplasmrosette菊形團SeedingthroughCSFHighlymalignantII.Medulloblastoma

髓母細胞瘤醫學課件園<20yII.Medulloblastoma醫學課件15Medulloblastoma醫學課件園Medulloblastoma醫學課件園www.yxkj16醫學課件園醫學課件園17Seedingofmedulloblastoma醫學課件園Seedingofmedulloblastoma醫學課件18

From:arachnoidcell蛛網膜細胞

部位:~arachnoidgranulationdura硬腦膜

大體：solid,gritty砂粒樣

光鏡：whorl-likepatternpsammoma砂粒體Malignant:rareIII.Meningioma腦膜瘤醫學課件園III.Meningioma腦膜瘤醫學課件園www19meningioma醫學課件園meningioma醫學課件園20Hereisanotherbenignmeningiomabeneaththedura.Theseneoplasmsareslowgrowing,butmayreachalargesizebeforesymptomsleadtodetection.醫學課件園Hereisanotherbenignmeningi21Meningiomaofsphenoidwing醫學課件園Meningiomaofsphenoidwing醫學課22醫學課件園醫學課件園23醫學課件園醫學課件園24醫學課件園醫學課件園25From:Schwanncell大體:encapsulated,solitary~nerves,spinalroots光鏡:Spindletumorcells,

排列成束狀，網狀BenignIV.Neurilemmoma神經鞘瘤Schwannoma醫學課件園From:SchwanncellIV.Neuril26Acousticschwannoma醫學課件園Acousticschwannoma醫學課件園www.y27Schwannomaofaspinalroot醫學課件園Schwannomaofaspinalroot醫學28Acousticschwannoma醫學課件園Acousticschwannoma醫學課件園www.y29Gemistocytixastrocytoma醫學課件園Gemistocytixastrocytoma醫學課件園30Gemistocytixastrocytoma醫學課件園Gemistocytixastrocytoma醫學課件園31Schwannoma醫學課件園