Cancermetastasis

腫瘤轉移英文版Whatismetastasis?CancerStemCells

motivateandmaintainthegrowthofcancercellspotentiality

plasticity

makethemeasytosurviveHypothesisoftumormetastasisThephasesofCancermetastasisThemechanismofcancermetastasisMalignantTumormetastasispathwayTumormetastasisThemoleculesinthemetastasisThephasesofCancermetastasis俞仁濤Invasion(侵犯)Intravasation（內滲）Extravasation（外滲）Invasion1.Stablecellmovablecell2.Proteinexpression3.MovementmechanismRelativegenesIntravasation1.Angiogenesis2.ImmuneescapeExtravasationTheinverseprocessofinvasionTHEPROCESSOFTUMORMETASTASISMalignantTumormetastasispathway

惡性腫瘤常見的轉移途徑

Commonmetastasispathway

1.

lymphaticmetastasis淋巴道轉移2.

hematogenousmetastasis

血道轉移3.implantationmetastasis種植性轉移Process：

cancercell

lymphvessel

regionallymphnode

beyond

lymphnode

hematogenousmetastasis

1.

Lymphaticmetastasize2.HematogenousmetastasislungliverMetastasispathway（1）Bodyveinlung（2）Portalveinliver（3）

pulmonaryveins

Totalbody（brain、

bone、

kidney、

adrenalglands）3.ImplantationmetastasisChestCeliacPericardialcavityBioremediation生物治療LowsideeffectsWiderangeCleargoalMechanismofcellmetastasisCelladhesionmolecule(CAM)DegradationofextracellularmatrixMotilityoftumorcellsFormationofvesselsRegulationofgeneexpressionImmunizationCelladhesionmolecule(CAM)CadherinIntegrinsSelectinIgSFothersDegradationofextracellularmatrix

絲氨酸蛋白酶類半胱氨酸蛋白酶類（Caspase家族）天冬氨酸蛋白酶類

基質金屬蛋白酶類（MMPs）Degradationofextracellularmatrix

Proteoiyticenzymes(蛋白水解酶)—溶解ECMECM是腫瘤侵襲和轉移的天然屏障Motilityoftumorcells

Motilitytypes:

RandommovementDirectionalmovementMotilityfactors:AutoecrineparacrineFormationofvessels

Tumormetastasisrelysontheformingofvessels.BriefIntroductiontoMolecules

inCancerMetastasisThreeSectionsTumourangiogenesisDisaggregationIntravasationTumourangiogenesis

Tumourangiogenesishaslaidthefoundationfortumoursurvivalandtumourmetastasis.