Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEAntibacterialagent121Cat.No.:HY-151354CASNo.:474099-18-8分?式:C??H??N?O?S分?量:346.44作?靶點:Bacterial作?通路:Anti-infection儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Antibacterialagent121(Compound10)?種抗劑。Antibacterialagent121具有抗霉和抗炎的活性，可?于肺結核相關研究。體外研究Antibacterialagent121(0.2-200μM;24h)inhibitsM.tuberculosisH37Rvgrowthinbacterialculture[1].Antibacterialagent121(0-200μM;24h)inhibitsNOproductioninLPS-stimulatedRAW264.7cellcultureswithanIC50valueof4.1μM[1].Antibacterialagent121(6.25-200μM,24h)inhibitsTNF-αandIL-1βproductioninLPS-stimulatedmacrophages[1].Antibacterialagent121(25-100μM,4d)inhibitsM.tuberculosisM299withanMIC50valueof24.8μM[1].CellViabilityAssay[1]CellLine:M.tuberculosisH37RvConcentration:0.2-200μMIncubationTime:24hoursResult:InhibitedMtbH37RvgrowthwithMIC50of8.6μM.CellViabilityAssay[1]CellLine:RAW264.7macrophagesandJ774A.1macrophagesConcentration:6.25-200μM1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEIncubationTime:24hoursResult:ShowedIC50valuesof15.3μMand28.4μMforTNF-αandIL-1βproduction,respectively.REFERENCES[1].SandersonDiasCalixto,etal.Antimycobacterialandanti-inflammatoryactivitiesofthioureaderivativesfocusingontreatmentapproachesforseverepulmonarytuberculosis.BioorgMedChem.2022Jan1;53:116506.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955