1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPhorbol 12,13-dibutyrateCat. No.: HY-18985CAS No.: 37558-16-0Synonyms: Phorbol dibutyrate; PDBu分式: CHO分量: 504.61作靶點: PKC作通路: Epigenetics; TGF-beta/Smad儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數據體外

2、實驗 DMSO : 125 mg/mL (247.72 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.9817 mL 9.9086 mL 19.8173 mL5 mM 0.3963 mL 1.9817 mL 3.9635 mL10 mM 0.1982 mL 0.9909 mL 1.9817 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗請根據您的實驗動物和給藥式選擇適當的溶解案，配制前請先配制澄的

3、儲備液，再依次添加助溶劑(為保證實驗結果的可靠性，體內實驗的作液，建議您現現配，當天使；澄的儲備液可以根據儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (4.12 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (4.12 mM); Clear solution1/2 Maste

4、r of Small Molecules 您邊的抑制劑師www.MedChemE3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (4.12 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Phorbol 12,13-dibutyrate (Phorbol dibutyrate)種 PKC 激活劑和有效的膚腫瘤啟動。IC50 & Target PKC 1體外研究 Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (1 MM) activates PKC

5、 and inhibited Na/K-ATPase transportactivity in OK cells 3.REFERENCES1. Singh J, et al. Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smoothmuscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G317-25.2. Szallasi Z, et al. Dis

6、sociation of phorbol esters leads to immediate redistribution to the cytosol of protein kinases C alpha and C delta inmouse keratinocytes. J Biol Chem. 1994 Nov 4;269(44):27159-62.3. Middleton JP, et al. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem.1993 Jul 25;268(21):15958-64.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: