ABCD152019211114181716432911012813765激素的結構及特點ABCD152019211114181716432911011醋酸氫化考的松(Hydrocortisoneacetate)OCH2OCOCH2OHOHOC醋酸氫化考的松(Hydrocortisoneacetate2醋酸氟氫考的松(Fludrocortisoneacetate)FOHOCH2OCOCH3OHOC醋酸氟氫考的松(Fludrocortisoneacetat3曲安奈德(Triamcinoloneacetonide.Kenelog)FOHOCH2OCOCH3OCOOCCH3CH3曲安奈德(Triamcinoloneacetonide.Ke4氟美松(Dexamethasone)FOCH2OHOCOHCH3HO氟美松(Dexamethasone)FOCH2OHOCOHC5膚輕松(醋酸仙乃樂，Fluocinonide)FOFCH2—OCOCH3OCHOOOCCH3CH3膚輕松(醋酸仙乃樂，Fluocinonide)FOFCH2—6丙酸氟替卡松丙酸氟替卡松7丙酸氟替卡松乳膏OFFHOCH3COSCH2FCH3OCOC2H5CH3HH丙酸氟替卡松乳膏OFFHOCH3COSCH2FCH3OCOC8倍他米松戊酸脂FOCH2OHOCHOO-C(CH2)3CH3OCH3倍他米松戊酸脂FOCH2OHOCHOO-C(CH2)3CH39氯氟舒松(Halcinonide)FOHOCH2CLOCOOCCH3CH3氯氟舒松(Halcinonide)FOHOCH2CLOCOO10氯倍他索丙酸酯(Clobetasol17-propionate)FOHOCH2CLOCOCOC2H3CH3氯倍他索丙酸酯(Clobetasol17-propiona11鹵關他松(Halomethasonemonohydric，Sicorten)FOHOCH2OHOCCH3H2OCLF鹵關他松(Halomethasonemonohydric，12鹵倍他索丙酸酯(HalobetasolPropionate)FOHOCH2CLOCOCOC2H3CH3F鹵倍他索丙酸酯(HalobetasolPropionate13雙醋二氟松(Psorcon，索康)FOCH2OC—CH3OCOC—CH3CH3FO雙醋二氟松(Psorcon，索康)FOCH2OC—CH3OC1417a丁酸酯氫化考的松(Hydrocortisone17-butyrate)OCH2OHOCO-C(CH2)2CH3HOO17a丁酸酯氫化考的松(Hydrocortisone1715地奈德(desonide)OOHOOHOCH3HHHOCH3CH3CH3地奈德(desonide)OOHOOHOCH3HHHOCH316糠酸莫米松(Mometasonefruoate)CLOHOCH2CLOCCH3OCO糠酸莫米松(Mometasonefruoate)CLOHO17OHOCH2OHOCOH16916cortisolOHOCH2OHOCOH16916cortisol18FOHOOCOFluticasonePropionateFSFH2CCOC2H1CH3FOHOOCOFluticasonePropionateF19FOHOOCOInactivecarboxylicacidderivateFCOC2H3CH3HOFOHOOCOInactivecarboxylicaci20潑尼松龍潑尼松龍21身體部分治療區域一次所需藥物的指尖單位量（無性別差異）頭和頸軀干（前）軀干（后）手臂手腳腿4.5773162身體部分治療區域一次所需頭和頸軀干（前）手臂手腳腿4.57322

圖1.考的索分子結構，FP及其無活性代謝產物。在1，6，9位的結構修飾加強了抗炎和鹽皮質激素的活性。兩個酯化天然結構大大提高了FP天然親脂性和藥物利用。快速代謝為非活性產物一半歸因于取代的硫化酯解離，一半為17羧酸代謝產物帶來的低系統活性。圖1.考的索分子結構，FP及其無活性代謝產物23ABCD152019211114181716432911012813765激素的結構及特點ABCD1520192111141817164329110124醋酸氫化考的松(Hydrocortisoneacetate)OCH2OCOCH2OHOHOC醋酸氫化考的松(Hydrocortisoneacetate25醋酸氟氫考的松(Fludrocortisoneacetate)FOHOCH2OCOCH3OHOC醋酸氟氫考的松(Fludrocortisoneacetat26曲安奈德(Triamcinoloneacetonide.Kenelog)FOHOCH2OCOCH3OCOOCCH3CH3曲安奈德(Triamcinoloneacetonide.Ke27氟美松(Dexamethasone)FOCH2OHOCOHCH3HO氟美松(Dexamethasone)FOCH2OHOCOHC28膚輕松(醋酸仙乃樂，Fluocinonide)FOFCH2—OCOCH3OCHOOOCCH3CH3膚輕松(醋酸仙乃樂，Fluocinonide)FOFCH2—29丙酸氟替卡松丙酸氟替卡松30丙酸氟替卡松乳膏OFFHOCH3COSCH2FCH3OCOC2H5CH3HH丙酸氟替卡松乳膏OFFHOCH3COSCH2FCH3OCOC31倍他米松戊酸脂FOCH2OHOCHOO-C(CH2)3CH3OCH3倍他米松戊酸脂FOCH2OHOCHOO-C(CH2)3CH332氯氟舒松(Halcinonide)FOHOCH2CLOCOOCCH3CH3氯氟舒松(Halcinonide)FOHOCH2CLOCOO33氯倍他索丙酸酯(Clobetasol17-propionate)FOHOCH2CLOCOCOC2H3CH3氯倍他索丙酸酯(Clobetasol17-propiona34鹵關他松(Halomethasonemonohydric，Sicorten)FOHOCH2OHOCCH3H2OCLF鹵關他松(Halomethasonemonohydric，35鹵倍他索丙酸酯(HalobetasolPropionate)FOHOCH2CLOCOCOC2H3CH3F鹵倍他索丙酸酯(HalobetasolPropionate36雙醋二氟松(Psorcon，索康)FOCH2OC—CH3OCOC—CH3CH3FO雙醋二氟松(Psorcon，索康)FOCH2OC—CH3OC3717a丁酸酯氫化考的松(Hydrocortisone17-butyrate)OCH2OHOCO-C(CH2)2CH3HOO17a丁酸酯氫化考的松(Hydrocortisone1738地奈德(desonide)OOHOOHOCH3HHHOCH3CH3CH3地奈德(desonide)OOHOOHOCH3HHHOCH339糠酸莫米松(Mometasonefruoate)CLOHOCH2CLOCCH3OCO糠酸莫米松(Mometasonefruoate)CLOHO40OHOCH2OHOCOH16916cortisolOHOCH2OHOCOH16916cortisol41FOHOOCOFluticasonePropionateFSFH2CCOC2H1CH3FOHOOCOFluticasonePropionateF42FOHOOCOInactivecarboxylicacidderivateFCOC2H3CH3HOFOHOOCOInactivecarboxylicaci43潑尼松龍潑尼松龍44身體部分治療區域一次所需藥物的指尖單位量（無性別差異）頭和頸軀干（前）軀干（后）手臂手腳腿4.577316