1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMPEP HydrochlorideCat. No.: HY-14609CAS No.: 219911-35-0分式: CHClN分量: 229.7作靶點: mGluR作通路: GPCR/G Protein; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數據體外實驗 H2O : 50 mg/mL (217.68 mM

2、)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.3535 mL 21.7675 mL 43.5350 mL5 mM 0.8707 mL 4.3535 mL 8.7070 mL10 mM 0.4354 mL 2.1768 mL 4.3535 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 MPEP鹽酸鹽競爭性mGlu5受體拮抗劑，IC50為36 nM。REFERENCE

3、S1. Inta, Dragos; Filipovic, Dragana; Lima-Ojeda, Juan M. et al. The mGlu5 receptor antagonist MPEP activates specific stress-related brainregions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: Significance for the use as anxiolytic/ant1/2 Master of Small Molecules 您邊的抑制劑師www.M

4、edChemE2. Chau, Peipei; Soederpalm, Bo; Ericson, Mia The mGluR5 antagonist MPEP elevates accumbal dopamine and glycine levels; interactionwith strychnine-sensitive glycine receptors. Addiction Biology (2011), 16(4), 591-599.3. DSouza, Manoranjan S.; Markou, Athina Metabotropic glutamate receptor 5 a

5、ntagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP)microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58955