Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESintilimab(Anti-PD-1)Cat.No.:HY-P99048ASynonyms:IBI308(Anti-PD-1)作?靶點(diǎn):PD-1/PD-L1作?通路:Immunology/Inflammation儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Sintilimab(Anti-PD-1)(IBI308(Anti-PD-1))?種安全有效的?的IgG4單克隆抗體，與PD-1結(jié)合，其KD值為74pM。Sintilimab(Anti-PD-1)阻斷PD-1與其配體(PD-L1和PL-L2)的相互作?，從?有助于恢復(fù)內(nèi)源性抗腫瘤T細(xì)胞反應(yīng)。Sintilimab(Anti-PD-1)聯(lián)合益?元抑制肺腺癌??腫瘤體積，調(diào)節(jié)免疫細(xì)胞亞群平衡。Sintilimab(Anti-PD-1)可?于經(jīng)典霍奇?淋巴瘤、??細(xì)胞肺癌和?管癌的研究[1][2][3][4][5]體外研究Sintilimab(150ng/μL,12h)showsahighlevelofPD-1occupancyandhassuperiorTcellactivatingcharacteristicsinhumanperipheralbloodmononuclearcells(PBMCs)[2]。體內(nèi)研究Sintilimab(0.1mg/kg,1mg/kgand10mg/kg,i.p.,asingledosefor1,8,12,15days)showsantitumoreffectsagainstNCI-H292tumorsinahumanizedmousemodel[2].Sintilimab(1mg/kg,3mg/kgand10mg/kg,s.c.,asingledose)demonstratesahighaffinityforPD-1moleculesinNCI-H292tumor-bearingNOGmice[2].Sintilimab(20mg/kg,i.p.,onceinterval2daysfor21days)combinedwithprebioticsinhibitsthevolumeoftransplantedtumorsinlungadenocarcinomaandalleviatestheliverandkidneyinjury[4].PharmacokineticparametersofSintilimab(10mg/kg,i.v.,asingledose)inhPD-1knock-inmouse[2]ParameterAUC0-4(h·μg/mL)AUCinf(h·μg/mL)CL(mL/h)Cmax(μg/mL)T1/2(h)Vss(mL)Sintilimab6597.8887846.5540.025218.51935.6231.262REFERENCES[1].SheridanMHoy.Sintilimab:FirstGlobalApprovalDrugs.2019Feb;79(3):341-346.[2].WangJ,etalDurableblockadeofPD-1signalinglinkspreclinicalefficacyofsintilimabtoitsclinicalbenefit.MAbs.2019Nov-1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEDec;11(8):1443-1451.[3].ZhangL,etal.Sintilimab:APromisingAnti-TumorPD-1Antibody.FrontOncol.2020Nov26;10:594558.[4].YanQ,etal.PrebioticsModulateGutMicrobiota-mediatedT-cellImmunitytoEnhancetheInhibitoryEffectofSintilimabinLewisLungAdenocarcinomaModelMice.AnticancerAgentsMedChem.2023;23(17):1966-1973.[5].ZhangL,etal.Sintilimabforthetreatmentofnon-smallcelllungcancer.BiomarkRes.2022Apr18;10(1):23.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchu