Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEApstatinTFACat.No.:HY-128090A分?式:C??H??F?N?O?分?量:573.56作?靶點:Aminopeptidase作?通路:MetabolicEnzyme/Protease儲存?式:Sealedstorage,awayfrommoisturePowder-80°C2years-20°C1yearInsolvent-80°C6months-20°C1month溶解性數據體外實驗DMSO:125mg/mL(217.94mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.7435mL8.7175mL17.4350mL5mM0.3487mL1.7435mL3.4870mL10mM0.1743mL0.8717mL1.7435mL請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。BIOLOGICALACTIVITY?物活性ApstatinTFA?種有效的氨肽酶P(aminopeptidaseP(APP))抑制劑，對??和?類APP的Ki值分別為2.6、0.64μM。ApstatinTFA具有?臟保護作?[1][2]。體內研究Apstatin(1mg/kg;i.v.;5?minbeforeischaemia)TFAreducesmyocardialinfarctsize(IS)inacutemyocardialischaemiamodel[1].1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEAnimalModel:270-310g,MaleWistarrats[1]Dosage:1mg/kgAdministration:I.v.;5?minbeforeischaemiaResult:Significantlyreducedinfarctsize(IS)inacutemyocardialischaemia.REFERENCES[1].WolfrumS,etal.Apstatin,aselectiveinhibitorofaminopeptidaseP,reducesmyocardialinfarctsizebyakinin-dependentpathway.BrJPharmacol.2001Sep;134(2):370-4.[2].MaggioraLL,etal.ApstatinanalogueinhibitorsofaminopeptidaseP,abradykinin-degradingenzyme.JMedChem.1999Jul1;42(13):2394-402.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589559